3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

Base Information

Chemical Name:3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide
CAS No.:1321992-12-4
Molecular Formula:C₃₃H₃₈N₄O₂
Molecular Weight:522.69
Hs Code.:

Synonyms:

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Chemical Property of 3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

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Technology Process of 3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

There total 7 articles about 3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1321992-10-2
3-(6-bromo-2-(4-methoxybenzylamino)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

: 1321992-12-4
3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,3-dioxane / 4 h / 85 °C / Inert atmosphere

2: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol / 12 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; In 1,3-dioxane; ethanol;
DOI:10.1021/jm200544q

Reference yield:

: 1309365-83-0
6-bromo-2-((4-methoxybenzyl)amino)quinoline-3-carbaldehyde

: 1321992-12-4
3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 12 h / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,3-dioxane / 4 h / 85 °C / Inert atmosphere

5: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol / 12 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; 1,3-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; acetonitrile; 1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm200544q

Reference yield:

: 1321992-39-5
ethyl 3-(2-(4-methoxybenzylamino)-6-bromoquinolin-3-yl)-2-methylacrylate

: 1321992-12-4
3-(2-(4-methoxybenzylamino)-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C / Inert atmosphere

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,3-dioxane / 4 h / 85 °C / Inert atmosphere

4: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol / 12 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetra fluoroborate; potassium acetate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,3-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol;
DOI:10.1021/jm200544q