tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Base Information

Chemical Name:tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate
CAS No.:1204417-53-7
Molecular Formula:C₃₇H₅₀N₄O₇S
Molecular Weight:694.893
Hs Code.:

tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

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Chemical Property of tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

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Technology Process of tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

There total 8 articles about tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204417-52-6
tert-butyl (1aS,12bR)-8-cyclohexyl-11-methoxy-1a-(methyl{2-[2-(methylamino)ethoxy]ethyl}carbamoyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

: 1204417-53-7
tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: With SULFAMIDE; In dichloromethane; at 100 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1021/jm401396p

Reference yield:

: cycloprop[d]indolo[2,1-a][2]benzazepine-1a, 5(2H)-dicarboxylic acid, 8-cyclohexyl-1,12b-dihydro-11-methoxy-, 5-(1,1-dimethylethyl) 1a-methyl ester, (+/-)

: 1204417-53-7
tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 2.5 h / 0 °C

3: n-butyllithium / tetrahydrofuran / -78 °C

4: sodium hydroxide / tetrahydrofuran / 20 - 30 °C

5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran

6: SULFAMIDE / dichloromethane / 0.33 h / 100 °C / Microwave irradiation

With n-butyllithium; oxalyl dichloride; SULFAMIDE; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401396p

Reference yield:

: 2620-27-1
1,5-bis(methylamino)-3-oxapentane

: 1204417-53-7
tert-butyl (1aS,12bR)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]-ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydro-cyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran

2: SULFAMIDE / dichloromethane / 0.33 h / 100 °C / Microwave irradiation

With SULFAMIDE; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401396p