13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

Base Information

Chemical Name:13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester
CAS No.:928844-30-8
Molecular Formula:C₃₁H₃₅NO₅
Molecular Weight:501.623
Hs Code.:

Synonyms:13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

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Chemical Property of 13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

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Technology Process of 13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

There total 10 articles about 13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 958002-18-1
1H-indole-6-carboxylic acid, 3-cyclohexyl-2-(2-formyl-4-methoxyphenyl)-, 1,1-dimethylethyl ester

: 55168-74-6
trimethyl 2-phosphonoacrylate

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 4h;

Reference yield:

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 70 °C

2: caesium carbonate / N,N-dimethyl-formamide / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; caesium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.113

Reference yield:

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2 - 2.67 h / 0 - 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

2.2: 1 h / 0 - 20 °C

3.1: silver carbonate / dichloromethane / 0 - 20 °C / Molecular sieve

4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 0.25 h

4.2: 4 h / 85 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

With lithium hydroxide; pyridinium hydrobromide perbromide; water; sodium carbonate; caesium carbonate; silver carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;