Technology Process of 2-(methoxymethyl)-4-nitro-1,2,3,5,6,7-hexahydro-s-indacene
There total 7 articles about 2-(methoxymethyl)-4-nitro-1,2,3,5,6,7-hexahydro-s-indacene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-nitro-1,2,3,5,6,7-hexahydro-s-indacen-2-yl)methanol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / dichloromethane / 8 h / 0 - 10 °C / Large scale
2.1: sulfuric acid / 48 h / 55 °C
2.2: 2 h / 0 - 10 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
3.2: 16 h / 25 °C
4.1: trifluoroacetic acid; triethylsilane / 16 h / 70 °C
5.1: diisobutylaluminium hydride / tetrahydrofuran / 16 h / -78 - 20 °C
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
6.2: 1 h / 20 °C
With
triethylsilane; aluminum (III) chloride; sulfuric acid; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid / 48 h / 55 °C
1.2: 2 h / 0 - 10 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
2.2: 16 h / 25 °C
3.1: trifluoroacetic acid; triethylsilane / 16 h / 70 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran / 16 h / -78 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
5.2: 1 h / 20 °C
With
triethylsilane; sulfuric acid; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran;
