8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one

Base Information

Chemical Name:8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one
CAS No.:43057-26-7
Molecular Formula:C₁₇H₁₃ClN₄O
Molecular Weight:324.769
Hs Code.:
UNII:D5K5H4678D
ChEMBL ID:CHEMBL335096
Wikidata:Q27276128

Synonyms:UNII-D5K5H4678D;D5K5H4678D;8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one;43057-26-7;1H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepin-1-one, 8-chloro-2,4-dihydro-2-methyl-6-phenyl-;CHEMBL335096;SCHEMBL11108457;Q27276128;8-chloro-2-methyl-6-phenyl-2,4-dihydro-1H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-one

Suppliers and Price of 8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:324.0777887
Heavy Atom Count:23
Complexity:555

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C(=O)N2C(=N1)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4

Technology Process of 8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one

There total 6 articles about 8-Chloro-2,4-dihydro-2-methyl-6-phenyl-1H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39667-62-4
1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

: 43057-26-7
8-chloro-2,4-dihydro-2-methyl-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80.6 percent / 85percent aq. H₃PO₄ / 6.67 h / 118 - 121 °C

2: CH₂Cl₂; methanol; diethyl ether / 0.67 h / 0 °C

With phosphoric acid; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00178a010

Reference yield:

: 4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

: 43057-26-7
8-chloro-2,4-dihydro-2-methyl-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / ethanol / 24 h / Heating

2: 64.4 percent / 0.25 h / 197 - 207 °C

3: CH₂Cl₂; methanol; diethyl ether / 0.67 h / 0 °C

In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00178a010