(2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine

Base Information

• Chemical Name: (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine
• CAS No.: 123811-85-8
• Molecular Formula: C₁₂H₂₃N*C₁₃H₂₃NO₄
• Molecular Weight: 438.651
• Mol file: 123811-85-8.mol

Synonyms:

Chemical Property of (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine

There total 5 articles about (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethylpyridine-1-oxide (14906-55-9) → (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine (123811-85-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / dimethylcarbamyl chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: 61 percent / 6 N HCl / 24 h / Heating

3: 100 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

4: 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5

5: diethyl ether / 4 h

With hydrogenchloride; sodium hydroxide; hydrogen; N,N-Dimethylcarbamoyl chloride; platinum(IV) oxide; In diethyl ether; ethanol; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jo00289a058

Reference yield:

2-cyano-4-ethylpyridine (92486-38-9) → (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine (123811-85-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / 6 N HCl / 24 h / Heating

2: 100 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

3: 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5

4: diethyl ether / 4 h

With hydrogenchloride; sodium hydroxide; hydrogen; platinum(IV) oxide; In diethyl ether; ethanol; water; tert-butyl alcohol;

DOI:10.1021/jo00289a058

Reference yield:

4-ethyl-2-pyridinecarboxylic acid hydrochloride (79415-18-2) → (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine (123811-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / hydrogen / platinum oxide / ethanol; H₂O / 24 h / 60 °C / 3102.9 Torr

2: 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5

3: diethyl ether / 4 h

With sodium hydroxide; hydrogen; platinum(IV) oxide; In diethyl ether; ethanol; water; tert-butyl alcohol;

DOI:10.1021/jo00289a058

upstream raw materials:

4-ethyl-BOC-DL-homoproline

N-cyclohexyl-cyclohexanamine

4-ethylpyridine-1-oxide

2-cyano-4-ethylpyridine