C₇₅H₁₅₂O₈S₂Si₅

Base Information

• Chemical Name: C₇₅H₁₅₂O₈S₂Si₅
• CAS No.: 118977-91-6
• Molecular Formula: C₇₅H₁₅₂O₈S₂Si₅
• Molecular Weight: 1386.59
• Mol file: 118977-91-6.mol

Synonyms:

Chemical Property of C₇₅H₁₅₂O₈S₂Si₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₅H₁₅₂O₈S₂Si₅

There total 17 articles about C₇₅H₁₅₂O₈S₂Si₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-9-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-6-methoxy-2,8-dimethyl-5-phenylacetoxy-nonyl ester → C75H152O8S2Si5 (118977-91-6,126923-00-0)

Guidance literature:

Multi-step reaction with 8 steps

1: NaH / tetrahydrofuran / 0 °C

2: H₂ / Pd(OH)2 / ethyl acetate

3: 2,6-lutidine / CH₂Cl₂

4: TFA / H₂O; tetrahydrofuran / 20 °C

6: pyridine / 0 °C

7: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

8: 1.) n-Buli, 2.) KHMDS / 1.) THF, -78 deg C, 2.) THF, O deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;

DOI:10.1021/ja00185a071

Reference yield:

Phenyl-acetic acid (1R,2S,4R)-5-(tert-butyl-dimethyl-silanyloxy)-1-((1S,3R)-1,4-dihydroxy-3-methyl-butyl)-2-methoxy-4-methyl-pentyl ester → C75H152O8S2Si5 (118977-91-6,126923-00-0)

Guidance literature:

Multi-step reaction with 9 steps

1: pyridine / 0 °C

2: NaH / tetrahydrofuran / 0 °C

3: H₂ / Pd(OH)2 / ethyl acetate

4: 2,6-lutidine / CH₂Cl₂

5: TFA / H₂O; tetrahydrofuran / 20 °C

7: pyridine / 0 °C

8: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

9: 1.) n-Buli, 2.) KHMDS / 1.) THF, -78 deg C, 2.) THF, O deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; potassium hexamethylsilazane; sodium hydride; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;

DOI:10.1021/ja00185a071

Reference yield:

2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-9-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-5-phenylacetoxy-nonyl ester → C75H152O8S2Si5 (118977-91-6,126923-00-0)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂ / Pd(OH)2 / ethyl acetate

2: 2,6-lutidine / CH₂Cl₂

3: TFA / H₂O; tetrahydrofuran / 20 °C

5: pyridine / 0 °C

6: 1.) n-BuLi / 1.) THF, -78 deg C, 2.) 0 deg C

7: 1.) n-Buli, 2.) KHMDS / 1.) THF, -78 deg C, 2.) THF, O deg C

With 2,6-dimethylpyridine; n-butyllithium; hydrogen; potassium hexamethylsilazane; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; water; ethyl acetate;

DOI:10.1021/ja00185a071

upstream raw materials:

tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane

(E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal

t-butyldimethylsiyl triflate

(2R,4S,5R,6S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonan-1-ol

Downstream raw materials:

C₆₉H₁₃₈O₈S₂Si₄

C₈₀H₁₅₅NO₁₁S₂Si₄