4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate

Base Information

• Chemical Name: 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate
• CAS No.: 123715-64-0
• Molecular Formula: C₃₆H₄₄O₇S
• Molecular Weight: 620.807
• Mol file: 123715-64-0.mol

Synonyms:

Chemical Property of 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate

There total 5 articles about 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

acetic anhydride (108-24-7) + 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 17-benzoate 19-p-toluenesulfonate (123715-63-9) → 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate (123715-64-0)

Guidance literature:

In pyridine; for 20h; Ambient temperature;

Reference yield:

17β,19-dihydroxyadrost-4-en-3-one 17-benzoate 19-p-toluenesulfonate (79884-57-4) → 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate (123715-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaBH₄ / ethyl acetate; methanol / 1 h

2: Zn/Cu, I₂

3: 78 percent / pyridine / 20 h / Ambient temperature

With sodium tetrahydroborate; iodine; copper; zinc; In pyridine; methanol; ethyl acetate;

Reference yield:

4-androstene-3β,17β,19-triol 17-benzoate 19-p-toluenesulfonate (123715-62-8) → 4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 3-acetate 17-benzoate 19-p-toluenesulfonate (123715-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn/Cu, I₂

2: 78 percent / pyridine / 20 h / Ambient temperature

With iodine; copper; zinc; In pyridine;

upstream raw materials:

acetic anhydride

4β,5-cyclopropano-5β-androstane-3β,17β,19-triol 17-benzoate 19-p-toluenesulfonate

4-androstene-3β,17β,19-triol 17-benzoate 19-p-toluenesulfonate

17β,19-dihydroxyadrost-4-en-3-one 17-benzoate 19-p-toluenesulfonate

Downstream raw materials:

4β,5-cyclopropano-5(10a)-homo-19-nor-5β-adrosta-1(10),2-dien-17β-ol 17-benzoate

4β,5-cyclopropano-5(10a)-homo-19-nor-5β-adrosta-1(10)-ene-3α,17β-diol 3-acetate 17-benzoate

4β,10β-cyclo-5(10a)-homo-19-nor-5β-androstane-3β,5,17β-triol 3,5-diacetate 17-benzoate

Refernces