Technology Process of (αS,1S)-α-[N-(1-methyl)benzyl]-β-[4'-(dimethylamino)benzoyl]alanine
There total 5 articles about (αS,1S)-α-[N-(1-methyl)benzyl]-β-[4'-(dimethylamino)benzoyl]alanine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: p-toluenesulfonic acid / benzene / 4 h / Heating
2: ethanol / 24 h / 50 - 60 °C
With
toluene-4-sulfonic acid;
In
ethanol; benzene;
2: Michael addition;
DOI:10.3390/12051170
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: anhydrous aluminum chloride / 1,1,2,2-tetrachloro-ethane / 0 °C
1.2: 91 percent / 1,1,2,2-tetrachloro-ethane / 0 - 20 °C
2.1: 33 percent / Li; HMPA / benzene / 24 h / 20 °C
3.1: tetramethylammonium hydroxide / methanol / 0 - 20 °C
4.1: p-toluenesulfonic acid / benzene / 4 h / Heating
5.1: ethanol / 24 h / 50 - 60 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; aluminium trichloride; tetramethyl ammoniumhydroxide; lithium; toluene-4-sulfonic acid;
In
methanol; ethanol; 1,1,2,2-tetrachloroethane; benzene;
1.2: Friedel-Crafts reaction / 5.1: Michael addition;
DOI:10.3390/12051170
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetramethylammonium hydroxide / methanol / 0 - 20 °C
2: p-toluenesulfonic acid / benzene / 4 h / Heating
3: ethanol / 24 h / 50 - 60 °C
With
tetramethyl ammoniumhydroxide; toluene-4-sulfonic acid;
In
methanol; ethanol; benzene;
3: Michael addition;
DOI:10.3390/12051170
