3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

Base Information

Chemical Name:3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide
CAS No.:935445-86-6
Molecular Formula:C₃₄H₂₉N₇O₅S₂
Molecular Weight:679.78
Hs Code.:

3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-<i>b</i>]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-<i>p</i>-tolylamide

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Chemical Property of 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

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Technology Process of 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

There total 5 articles about 3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 935445-78-6
6-({2-[(4-tolyl)amino]-2-oxoethyl}thio)-5-cyano-4-(4-methoxyphenyl)-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}nicotinamide

: 935445-86-6
3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

Guidance literature:: With sodium ethanolate; In ethanol; for 1h; Heating;
DOI:10.1080/10426500600614808

Reference yield:

: 68-35-9
sulfadiazine

: 935445-86-6
3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 0.25 h / 140 °C

2: 60 percent / triethylamine / ethanol / 2 h / Heating

3: 50 percent / AcONa / ethanol / 1 h / Heating

4: 25 percent / EtONa / ethanol / 1 h / Heating

With sodium ethanolate; sodium acetate; triethylamine; In ethanol;
DOI:10.1080/10426500600614808

Reference yield:

: 134477-88-6
3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide

: 935445-86-6
3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2,5-dicarboxylic acid 5-{[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-amide} 2-p-tolylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / triethylamine / ethanol / 2 h / Heating

2: 50 percent / AcONa / ethanol / 1 h / Heating

3: 25 percent / EtONa / ethanol / 1 h / Heating

With sodium ethanolate; sodium acetate; triethylamine; In ethanol;
DOI:10.1080/10426500600614808