C₄₈H₄₈ClN₄O₁₃P

Base Information

• Chemical Name: C₄₈H₄₈ClN₄O₁₃P
• CAS No.: 182810-28-2
• Molecular Formula: C₄₈H₄₈ClN₄O₁₃P
• Molecular Weight: 955.355
• Mol file: 182810-28-2.mol

Synonyms:

Chemical Property of C₄₈H₄₈ClN₄O₁₃P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₄₈ClN₄O₁₃P

There total 10 articles about C₄₈H₄₈ClN₄O₁₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C48H48ClN4O13P (182810-28-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 95 percent / pyridine

2: 82 percent / 80percent acetic acid

5: 1.) 2-nitrobenzaldoxim, 1,1,3,3-tetramethylquanidine / 1.) aqueous dioxane

6: 61 percent / 2,4,6-triisopropylbenzenesulfonylchloride, 1-methylimidazole / CH₂Cl₂

7: 50 percent / 0.5 M HCl / methanol

8: tetrabutylammonium perchlorate / pyridine

With 1-methyl-1H-imidazole; hydrogenchloride; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammonium perchlorate; acetic acid; N,N,N',N'-tetramethylguanidine; 2-nitrobenzaldehyde oxime; In pyridine; methanol; dichloromethane;

DOI:10.1016/0040-4039(96)01380-9

Reference yield:

di(2-chlorophenyl) chloromethylphosphonate (105972-87-0) → C48H48ClN4O13P (182810-28-2)

Guidance literature:

Multi-step reaction with 6 steps

3: 1.) 2-nitrobenzaldoxim, 1,1,3,3-tetramethylquanidine / 1.) aqueous dioxane

4: 61 percent / 2,4,6-triisopropylbenzenesulfonylchloride, 1-methylimidazole / CH₂Cl₂

5: 50 percent / 0.5 M HCl / methanol

6: tetrabutylammonium perchlorate / pyridine

With 1-methyl-1H-imidazole; hydrogenchloride; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammonium perchlorate; N,N,N',N'-tetramethylguanidine; 2-nitrobenzaldehyde oxime; In pyridine; methanol; dichloromethane;

DOI:10.1016/0040-4039(96)01380-9

Reference yield:

3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde (131118-61-1) → C48H48ClN4O13P (182810-28-2)

Guidance literature:

Multi-step reaction with 5 steps

2: 1.) 2-nitrobenzaldoxim, 1,1,3,3-tetramethylquanidine / 1.) aqueous dioxane

3: 61 percent / 2,4,6-triisopropylbenzenesulfonylchloride, 1-methylimidazole / CH₂Cl₂

4: 50 percent / 0.5 M HCl / methanol

5: tetrabutylammonium perchlorate / pyridine

With 1-methyl-1H-imidazole; hydrogenchloride; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammonium perchlorate; N,N,N',N'-tetramethylguanidine; 2-nitrobenzaldehyde oxime; In pyridine; methanol; dichloromethane;

DOI:10.1016/0040-4039(96)01380-9

upstream raw materials:

4,4'-dimethoxytrityl chloride

C₂₇H₃₀ClN₄O₁₁P

di(2-chlorophenyl) chloromethylphosphonate

5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine