4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)

Base Information

• Chemical Name: 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
• CAS No.: 1194-74-7
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.142
• Hs Code.: 2933599090
• Mol file: 1194-74-7.mol

Synonyms:4(1H)-Pyrimidinone,6-hydroxy-2,5-dimethyl- (9CI);4,6-Pyrimidinediol, 2,5-dimethyl- (7CI,8CI);2,5-Dimethyl-4,6-dihydroxypyrimidine;2,5-Dimethylpyrimidine-4,6-diol;4,6-Dihydroxy-2,5-dimethylpyrimidine;NSC 40214;

Chemical Property of 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.000549mmHg at 25°C
• Melting Point: >360 °C
• Refractive Index: 1.599
• Boiling Point: 302.5 °C at 760 mmHg
• PKA: 6.93±0.10(Predicted)
• Flash Point: 136.8 °C
• PSA: 65.98000
• Density: 1.36 g/cm³
• LogP: 0.09230
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,?5-?Dimethylpyrimidine-?4,?6-?diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dimethylpyrimidine-4,6-diol is a chemical reagent used in the synthesis of pharmaceutically active dimethylpyrimidines.

Technology Process of 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)

There total 4 articles about 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

Diethyl methylmalonate (609-08-5) → 4,6-Dihydroxy-2,5-dimethylpyrimidin (1194-74-7)

Guidance literature:

acetamidine hydrochloride; With sodium methylate; In methanol; at 0 - 20 ℃; for 0.333333h;

Diethyl methylmalonate; In methanol; for 3h;

With acetic acid; In water; pH=4 - 5;

Reference yield:

acetamidine hydrochloride (124-42-5) + Diethyl methylmalonate (609-08-5) → 4,6-Dihydroxy-2,5-dimethylpyrimidin (1194-74-7)

Guidance literature:

acetamidine hydrochloride; Diethyl methylmalonate; With sodium; In ethanol; for 2.5h; Heating / reflux;

With hydrogenchloride; In water; at 4 ℃; for 1h;

Reference yield:

methyl-malonic acid dimethylester (609-02-9) + acetamidine hydrochloride (124-42-5) → 4,6-Dihydroxy-2,5-dimethylpyrimidin (1194-74-7)

Guidance literature:

acetamidine hydrochloride; With sodium methylate; In methanol; at 0 ℃;

methyl-malonic acid dimethylester; In methanol; at 75 ℃; for 4h;

With hydrogenchloride; In water;

upstream raw materials:

acetamidine hydrochloride

Diethyl methylmalonate

methyl-malonic acid dimethylester

Downstream raw materials:

6-chloro-2,5-dimethyl-pyrimidin-4-ylamine

4,6-dichloro-2,5-dimethyl-pyrimidine

Refernces

• 1、 -. "HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF". Page/Page column 124. . Retrieved 2011/12/14.
• 2、 -. "Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same". Page/Page column 74-75. . Retrieved 2008/06/13.