(1S)-2,2-dimethyl-1-phenyl-1-propanol

Base Information

• Chemical Name: (1S)-2,2-dimethyl-1-phenyl-1-propanol
• CAS No.: 24867-90-1
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.247
• Mol file: 24867-90-1.mol

Synonyms:

Chemical Property of (1S)-2,2-dimethyl-1-phenyl-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-2,2-dimethyl-1-phenyl-1-propanol

There total 53 articles about (1S)-2,2-dimethyl-1-phenyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2-dimethylpropiophenone (938-16-9) → (1S)-2,2-dimethyl-1-phenyl-1-propanol (23439-91-0,57377-60-3,3835-64-1,24867-90-1)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; formic acid; (αR,2S)-(-)-1-(2-diphenylphosphinobenzyl)-α-(2,2-dimethylpropynyl)-2-pyrrolidinemethanol; potassium carbonate; at 40 ℃; for 6h; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.202000615

Reference yield: 95.0%

2,2-dimethylpropiophenone (938-16-9) → (1S)-2,2-dimethyl-1-phenyl-1-propanol (23439-91-0,57377-60-3,3835-64-1,24867-90-1) + 2,2-dimethyl-1-phenyl-1-propanol (23439-91-0)

Guidance literature:

With <<(1S,2R)-6,6-dimethylbicyclo<3.1.1>heptan-2-yl>methyl>aluminum dichloride; In diethyl ether; for 4h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jo00176a018

Reference yield: 92.0%

phenylzinc(II) bromide (38111-44-3) + pivalaldehyde (630-19-3) → (1S)-2,2-dimethyl-1-phenyl-1-propanol (23439-91-0,57377-60-3,3835-64-1,24867-90-1)

Guidance literature:

phenylzinc(II) bromide; With trimethylaluminum; (1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol; In tetrahydrofuran; toluene; at 20 ℃; for 0.333333h; Inert atmosphere;

pivalaldehyde; In tetrahydrofuran; toluene; at 20 ℃; for 17h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/chem.200901803

upstream raw materials:

2,2-dimethylpropiophenone

2,2-dimethyl-1-phenylpropan-1-ol

potassium phtalimide

(R)-1-phenyl-1-diphenylsiloxy-2,2-dimethylpropane

Downstream raw materials:

(-)-(S)-(1-chloro-2,2-dimethylpropyl)benzene

(S)-1-bromo-2,2-dimethyl-1-phenyl-propane

(E)-3-((S)-2,2-Dimethyl-1-phenyl-propoxy)-2-methyl-propenal

[(S)-2,2-Dimethyl-1-((E)-2-methyl-buta-1,3-dienyloxy)-propyl]-benzene