2-(l-Menthoxy)ethanol

Base Information

• Chemical Name: 2-(l-Menthoxy)ethanol
• CAS No.: 7378-38-3
• Molecular Formula: C₁₂H₂₄O₂
• Molecular Weight: 200.321
• UNII: KCP993E27T,5ZWW23169H
• Nikkaji Number: J3.152.070C
• Wikidata: Q76415285
• Metabolomics Workbench ID: 152485
• Mol file: 7378-38-3.mol

Synonyms:2-(l-Menthoxy)ethanol;Coolact5;2-l-Menthoxyethanol;2-(Laevo-menthoxy) ethanol;FEMA no. 4154;2-(l-Menthoxy)ethanol [FHFI];75443-64-0;UNII-KCP993E27T;UNII-5ZWW23169H;KCP993E27T;5ZWW23169H;2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexoxy)ethanol;Ethanol, 2-(((1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-;Ethanol, 2-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-, (1R-(1alpha,2beta,5alpha))-;Ethanol, 2-((5-methyl-2-(1-methylethyl)cyclohexyl)oxy)-;l-Menthoxyethanol;SCHEMBL3384739;3-(2-hydroxyethoxy)-p-menthane;DB11174;PD085719;2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyethanol;2-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}ethan-1-ol;7378-38-3;ETHANOL, 2-((5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL)OXY)-, (1.ALPHA.,2.BETA.,5.ALPHA.)-;ETHANOL, 2-((5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL)OXY)-, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-

Chemical Property of 2-(l-Menthoxy)ethanol

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 200.177630004
• Heavy Atom Count: 14
• Complexity: 156

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CCC(C(C1)OCCO)C(C)C
• Isomeric SMILES: C[C@@H]1CC[C@H]([C@@H](C1)OCCO)C(C)C

Technology Process of 2-(l-Menthoxy)ethanol

There total 4 articles about 2-(l-Menthoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

menthoxyacetic acid (40248-63-3) → 2-(L-menthoxy)ethanol (7378-38-3,38618-23-4,75443-64-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1055/s-1996-4300

Reference yield: 87.0%

methyl L-menthoxyacetate (43195-93-3) → 2-(L-menthoxy)ethanol (7378-38-3,38618-23-4,75443-64-0)

Guidance literature:

With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate; In methanol; at 80 ℃; for 5h; under 33753.4 Torr; Autoclave; Inert atmosphere;

DOI:10.1021/op200234j

Reference yield: 47.4%

oxirane (75-21-8,99932-75-9) + (-)-menthol (2216-51-5) → 2-(L-menthoxy)ethanol (7378-38-3,38618-23-4,75443-64-0)

Guidance literature:

With aluminum (III) chloride; In toluene; at 5 - 20 ℃; for 1h;

upstream raw materials:

menthoxyacetic acid

(-)-menthol

oxirane

methyl L-menthoxyacetate

Downstream raw materials:

1-menthoxyethylmethane sulfonate

di-[2-(l-menthoxy)ethanol-1] carbonate

L-menthyl-(L-menthoxyethyl)succinic ester

2-(l-menthoxy)ethan-1-ol-l-menthyl carbonate