6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin

Base Information

• Chemical Name: 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin
• CAS No.: 129749-72-0
• Molecular Formula: C₂₉H₃₄N₄O₆
• Molecular Weight: 534.612
• Mol file: 129749-72-0.mol

Synonyms:

Chemical Property of 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin

There total 7 articles about 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Dihydroxybenzoic acid (303-07-1) → 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin (129749-72-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / K₂CO₃ / acetone / 11 h / Heating

2: 76 percent / LiAlH₄ / diethyl ether / 1 h

3: 1.1 g / Collins' reagent / CH₂Cl₂ / 24 h / Ambient temperature

4: 75 percent / dimethylformamide / 16 h / 140 - 150 °C

5: 872 mg / H₂ / 10percent Pd-C / methanol / 5 h

6: 1.) dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 1h 2.) DMF, 1d

With lithium aluminium tetrahydride; Collins oxidation agent; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1248/cpb.38.312

Reference yield:

2,6-dibenzyloxybenzyl alcohol (25983-52-2) → 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin (129749-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.1 g / Collins' reagent / CH₂Cl₂ / 24 h / Ambient temperature

2: 75 percent / dimethylformamide / 16 h / 140 - 150 °C

3: 872 mg / H₂ / 10percent Pd-C / methanol / 5 h

4: 1.) dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 1h 2.) DMF, 1d

With Collins oxidation agent; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.312

Reference yield:

3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene (25983-53-3) → 6--1,5-dihydro-3-methyl-10-p-tolyl-5-deazaflavin (129749-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / dimethylformamide / 16 h / 140 - 150 °C

2: 872 mg / H₂ / 10percent Pd-C / methanol / 5 h

3: 1.) dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 1h 2.) DMF, 1d

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.312

upstream raw materials:

t-Boc-L-valine

1,5-dihydro-6-hydroxy-3-methyl-10-p-tolyl-5-deazaflavin

2,6-Dihydroxybenzoic acid

3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene

Downstream raw materials:

6--3-methyl-10-p-tolyl-5-deazaflavin