Technology Process of (2S,3aS,9bS)-6,7,8-Trimethoxy-2-propyl-2,3,3a,9b-tetrahydro-furo[3,2-c]isochromen-5-one
There total 11 articles about (2S,3aS,9bS)-6,7,8-Trimethoxy-2-propyl-2,3,3a,9b-tetrahydro-furo[3,2-c]isochromen-5-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetone;
at 20 ℃;
for 72h;
Inert atmosphere;
Darkness;
DOI:10.1021/jo400760q
- Guidance literature:
-
Multi-step reaction with 8 steps
1: calcium carbonate; iodine / tetrahydrofuran; water / 0 °C
2: samarium diiodide / tetrahydrofuran / 4 h / -10 °C / Inert atmosphere
3: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C
4: Jones reagent / acetone / 1 h / 0 °C
5: potassium carbonate / methanol / 3 h / 20 °C
6: boron trichloride / dichloromethane / 3 h / -10 °C / Inert atmosphere
7: [bis(acetoxy)iodo]benzene / dichloromethane / 1 h / 20 °C
8: potassium carbonate / acetone / 72 h / 20 °C / Inert atmosphere; Darkness
With
Jones reagent; samarium diiodide; trimethylsilyl trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; iodine; boron trichloride; potassium carbonate; calcium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone;
DOI:10.1021/jo400760q
- Guidance literature:
-
Multi-step reaction with 7 steps
1: samarium diiodide / tetrahydrofuran / 4 h / -10 °C / Inert atmosphere
2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 0 °C
3: Jones reagent / acetone / 1 h / 0 °C
4: potassium carbonate / methanol / 3 h / 20 °C
5: boron trichloride / dichloromethane / 3 h / -10 °C / Inert atmosphere
6: [bis(acetoxy)iodo]benzene / dichloromethane / 1 h / 20 °C
7: potassium carbonate / acetone / 72 h / 20 °C / Inert atmosphere; Darkness
With
Jones reagent; samarium diiodide; trimethylsilyl trifluoromethanesulfonate; [bis(acetoxy)iodo]benzene; boron trichloride; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo400760q