Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester
• CAS No.: 109875-69-6
• Molecular Formula: C₄₃H₄₁Cl₂N₃O₁₁P₂
• Molecular Weight: 908.666

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

There total 6 articles about Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) → Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (109875-69-6)

Guidance literature:

Multi-step reaction with 5 steps

1: diisopropylethylamine / CH₂Cl₂ / 2 h

2: 82 percent / hydrazine hydrate (NH₂NH₂*H₂O) / methanol / 1 h

4: 1.) NaOH (2N); 2.) HCl (2N) / 1.) MeOH, 0 deg C, 10 min; 2.) CH₂Cl₂

5: 2.) H₂O / 1.) CH₂Cl₂, 20 min

With hydrogenchloride; sodium hydroxide; water; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1248/cpb.35.2726

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (109875-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 0.25 h / 0 °C

2: 2.) H₂O / 1.) CH₂Cl₂, 20 min

With pyridine; water; In dichloromethane;

DOI:10.1248/cpb.35.2726

Reference yield:

2-(2-Trityloxy-ethylamino)-indan-1,3-dione → Phosphoric acid (2R,3S,5R)-2-[(2-chloro-phenoxy)-(2-trityloxy-ethylamino)-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester (109875-69-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / hydrazine hydrate (NH₂NH₂*H₂O) / methanol / 1 h

3: 1.) NaOH (2N); 2.) HCl (2N) / 1.) MeOH, 0 deg C, 10 min; 2.) CH₂Cl₂

4: 2.) H₂O / 1.) CH₂Cl₂, 20 min

With hydrogenchloride; sodium hydroxide; water; hydrazine hydrate; In methanol;

DOI:10.1248/cpb.35.2726

upstream raw materials:

(2-Trityloxy-ethyl)-phosphoramidic acid 2-chloro-phenyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

2-{[(triphenyl)methyl]oxy}ethylamine

trityl chloride

Downstream raw materials:

C₅₉H₅₆Cl₂N₆O₁₅P₂

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