hVEGF-IN-1

Base Information

Chemical Name:hVEGF-IN-1
CAS No.:1637443-98-1
Molecular Formula:C₃₄H₄₃N₇O₂
Molecular Weight:581.761
Hs Code.:
Mol file:1637443-98-1.mol

Synonyms:

Suppliers and Price of hVEGF-IN-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
hVEGF-IN-1 >98%
100 mg
$ 1100.00

ChemScene
hVEGF-IN-1 98.31%
10mg
$ 750.00

ChemScene
hVEGF-IN-1 98.31%
5mg
$ 450.00

ChemScene
hVEGF-IN-1 98.31%
1mg
$ 150.00

Total 8 raw suppliers

Chemical Property of hVEGF-IN-1

Chemical Property:

Boiling Point:710.9±60.0 °C(Predicted)
PKA:14.43±0.70(Predicted)
Density:1.188±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

hVEGF-IN-1 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of hVEGF-IN-1

There total 12 articles about hVEGF-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1637443-98-1
N-((2-(4-(N-(4-(2-diethylaminoethoxy))phenyl)amino)-quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: In methanol; Reflux;

Reference yield:

: 4-(N-4-(2-diethylaminoethoxy)phenyl)amino-2-(2-aminophenyl)quinazoline

: 1637443-98-1
N-((2-(4-(N-(4-(2-diethylaminoethoxy))phenyl)amino)-quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / chloroform / 24 h / 0 - 20 °C

2: methanol / 10 h / Reflux

With potassium carbonate; In methanol; chloroform;
DOI:10.1021/acs.jmedchem.6b01444

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1637443-98-1
N-((2-(4-(N-(4-(2-diethylaminoethoxy))phenyl)amino)-quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / chloroform / 10 h / 0 - 20 °C

2: potassium hydroxide / ethanol; water / 2 h / Reflux

3: trichlorophosphate / N,N-dimethyl-formamide; 1,4-dioxane / 6 h / 120 °C

4: hydrogenchloride / ethanol; water / 5 h / Reflux

5: boron tribromide / dichloromethane / 5 h / -78 - 20 °C

6: caesium carbonate / acetone / 24 h / Reflux

7: potassium carbonate / tetrahydrofuran / 24 h / Reflux

8: hydrazine hydrate; palladium 10% on activated carbon / isopropyl alcohol / 2 h / Reflux

9: potassium carbonate / chloroform / 24 h / 0 - 20 °C

10: methanol / 10 h / Reflux

With hydrogenchloride; hydrazine hydrate; palladium 10% on activated carbon; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1021/acs.jmedchem.6b01444