N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide

Base Information

• Chemical Name: N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide
• CAS No.: 67718-36-9
• Molecular Formula: C14H11N3O4
• Molecular Weight: 285.259
• Mol file: 67718-36-9.mol

Synonyms:N-(2-Nitro-benzoyl)-anthranilsaeure-amid;2-[(2-nitrophenyl)carbonylamino]benzamide;N-(2-carbamoylphenyl)-2-nitrobenzamide;N-(2-nitro-benzoyl)-anthranilic acid amide;O-(o'-nitrobenzamido)benzamid;

Chemical Property of N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide

Chemical Property:

• Melting Point: 210.2 - 213.5 °C (ethanol)
• PSA: 118.01000
• LogP: 3.24250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide

There total 11 articles about N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

anthranilic acid amide (28144-70-9,88-68-6) + 2-nitrobenzyl chloride (610-14-0) → N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide (67718-36-9)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.07.064

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) → N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide (67718-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 80 °C

2: 86 percent / triethylamine / CHCl₃ / 2 h / 20 °C

With thionyl chloride; triethylamine; In chloroform;

DOI:10.1016/j.tetlet.2006.07.064

Reference yield:

anthranilic acid nitrile (1885-29-6) → N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide (67718-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / KOH / ethanol / 2 h / Heating

2: 2.2 g / Et₃N / CHCl₃ / 2 h / 20 °C

With potassium hydroxide; triethylamine; In ethanol; chloroform;

DOI:10.1021/jo0518912

upstream raw materials:

2-(2'-nitrophenyl)-3,1-benzoxazin-4-one

anthranilic acid amide

2-nitrobenzyl chloride

ortho-nitrobenzoic acid

Downstream raw materials:

N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(pyrrolidin-1-yl)propanamido)benzamide

4-(3-(diethylamino)propanamido)-N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)benzamide

N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(2-(4-methylpiperazin-1-yl)acetamido)benzamide

N-(2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(2-morpholinoacetamido)benzamide