Technology Process of (benzyloxy-4 dimethoxy-3,5 phenyl)-1-r bis-hydroxymethyl-2-t, 3-c benzyloxy-7 methoxy-6 tetrahydro-1,2,3,4 naphtalene
There total 10 articles about (benzyloxy-4 dimethoxy-3,5 phenyl)-1-r bis-hydroxymethyl-2-t, 3-c benzyloxy-7 methoxy-6 tetrahydro-1,2,3,4 naphtalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / methylate de sodium / 7 h / Heating
2: 66.5 percent / chlorure de calcium, borohydrure de sodium / ethanol; aq. KOH / 1.) room temperature, 5 h; 2.) 0 deg C, pH=1 (HCl 6N); 3.) -20 deg C
3: 77.6 percent / H2 / Pd/C (10percent) / ethyl acetate / 7 h / 3750.3 Torr / Ambient temperature
4: 93.6 percent / carbonate de potassium, iodure de sodium / acetone / 15 h / Heating
5: 92 percent / hexamethyldisilylamidure de lithium / benzene; hexane / 1.) 0 to -20 deg C
6: 52 percent / H2 / Pd/C (10percent) / ethyl acetate; trifluoroacetic acid / 4 h / 3750.3 Torr / Ambient temperature
7: 66.6 percent / carbonate de potassium, iodure de sodium / acetone / Heating
8: 1.) AlLiH4; 2.) H2O / 1.) THF, 30 min, 15 deg C to room temperature; 2.) THF
With
sodium tetrahydroborate; lithium aluminium tetrahydride; chlorure de calcium; water; hydrogen; sodium methylate; potassium carbonate; sodium iodide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
potassium hydroxide; ethanol; hexane; ethyl acetate; acetone; trifluoroacetic acid; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93.6 percent / carbonate de potassium, iodure de sodium / acetone / 15 h / Heating
2: 92 percent / hexamethyldisilylamidure de lithium / benzene; hexane / 1.) 0 to -20 deg C
3: 52 percent / H2 / Pd/C (10percent) / ethyl acetate; trifluoroacetic acid / 4 h / 3750.3 Torr / Ambient temperature
4: 66.6 percent / carbonate de potassium, iodure de sodium / acetone / Heating
5: 1.) AlLiH4; 2.) H2O / 1.) THF, 30 min, 15 deg C to room temperature; 2.) THF
With
lithium aluminium tetrahydride; water; hydrogen; potassium carbonate; sodium iodide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
hexane; ethyl acetate; acetone; trifluoroacetic acid; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / hexamethyldisilylamidure de lithium / benzene; hexane / 1.) 0 to -20 deg C
2: 52 percent / H2 / Pd/C (10percent) / ethyl acetate; trifluoroacetic acid / 4 h / 3750.3 Torr / Ambient temperature
3: 66.6 percent / carbonate de potassium, iodure de sodium / acetone / Heating
4: 1.) AlLiH4; 2.) H2O / 1.) THF, 30 min, 15 deg C to room temperature; 2.) THF
With
lithium aluminium tetrahydride; water; hydrogen; potassium carbonate; sodium iodide; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
hexane; ethyl acetate; acetone; trifluoroacetic acid; benzene;
