3-benzyl-7-methoxy-4-chromanol

Base Information

• Chemical Name: 3-benzyl-7-methoxy-4-chromanol
• CAS No.: 76285-75-1
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 76285-75-1.mol

Synonyms:

Chemical Property of 3-benzyl-7-methoxy-4-chromanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-7-methoxy-4-chromanol

There total 6 articles about 3-benzyl-7-methoxy-4-chromanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-benzyl-7-methoxy-4-chromanone (76285-73-9) → 3-benzyl-7-methoxy-4-chromanol (76285-75-1)

Guidance literature:

With sodium tetrahydroborate; 1) methanol, 4 h, room temperature, 2) water, 30 min, steam-bath;

Reference yield:

O-methylresorcine (150-19-6) → 3-benzyl-7-methoxy-4-chromanol (76285-75-1)

Guidance literature:

Multi-step reaction with 6 steps

1: triton-B

2: procedure of Loudon et al.

3: 81 percent / PPA / 1.5 h / 60 °C

4: 75 percent / conc. HCl / ethanol / 4 h / Heating

5: 93 percent / H₂ (one mole equivalent) / Pd-C / ethyl acetate / Ambient temperature

6: 96 percent / NaBH₄ / 1) methanol, 4 h, room temperature, 2) water, 30 min, steam-bath

With hydrogenchloride; sodium tetrahydroborate; hydrogen; N-benzyl-trimethylammonium hydroxide; palladium on activated charcoal; In ethanol; ethyl acetate;

Reference yield:

β-(m-methoxyphenoxy)propionitrile (6279-84-1) → 3-benzyl-7-methoxy-4-chromanol (76285-75-1)

Guidance literature:

Multi-step reaction with 5 steps

1: procedure of Loudon et al.

2: 81 percent / PPA / 1.5 h / 60 °C

3: 75 percent / conc. HCl / ethanol / 4 h / Heating

4: 93 percent / H₂ (one mole equivalent) / Pd-C / ethyl acetate / Ambient temperature

5: 96 percent / NaBH₄ / 1) methanol, 4 h, room temperature, 2) water, 30 min, steam-bath

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;

upstream raw materials:

3-benzyl-7-methoxy-4-chromanone

O-methylresorcine

β-(m-methoxyphenoxy)propionitrile

3-(3-methoxyphenoxy)propionic acid

Downstream raw materials:

4-(p-hydroxyphenyl)-3-benzyl-7-methoxychroman

4--3-benzyl-7-methoxychroman

4--3-benzyl-7-methoxychroman

4-(p-acetoxyphenyl)-3-benzyl-7-methoxychroman

Refernces