Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

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Chemical Name:Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester
CAS No.:87875-27-2
Molecular Formula:C₃₇H₄₃Cl₂N₄O₁₃PSi
Molecular Weight:881.733
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

There total 8 articles about Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 87875-27-2
Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / SOCl₂, pyridine / 2 h / Heating

2: NaI / butan-2-one

3: 70 percent

4: NH₃ / methanol

5: 38 percent / imidazole / pyridine

7: p-toluenesulfonic acid

With pyridine; 1H-imidazole; thionyl chloride; ammonia; toluene-4-sulfonic acid; sodium iodide; In pyridine; methanol; butanone;
DOI:10.1016/S0040-4039(00)88175-7

Reference yield:

: 20264-95-3
2-(4-nitrophenyl)ethyl chloride

: 87875-27-2
Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaI / butan-2-one

2: 70 percent

3: NH₃ / methanol

4: 38 percent / imidazole / pyridine

6: p-toluenesulfonic acid

With 1H-imidazole; ammonia; toluene-4-sulfonic acid; sodium iodide; In pyridine; methanol; butanone;
DOI:10.1016/S0040-4039(00)88175-7

Reference yield:

: 20264-96-4
2-(4-nitrophenyl)ethyl iodide

: 87875-27-2
Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-5-{4-[2-(4-nitro-phenyl)-ethoxy]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent

2: NH₃ / methanol

3: 38 percent / imidazole / pyridine

5: p-toluenesulfonic acid

With 1H-imidazole; ammonia; toluene-4-sulfonic acid; In pyridine; methanol;
DOI:10.1016/S0040-4039(00)88175-7