(1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 210481-93-9
• Molecular Formula: C₃₁H₄₂F₃N₅O₆S
• Molecular Weight: 669.766
• Mol file: 210481-93-9.mol

Synonyms:

Chemical Property of (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 9 articles about (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-nitrophenyl)piperazine (59084-06-9) → (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (210481-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: HOBt, EDC

2: H₂ / Raney-Ni

3: Et₃N / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; nickel; In dichloromethane;

DOI:10.1016/S0960-894X(98)00238-8

Reference yield:

Boc-Aib-OH (30992-29-1) → (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (210481-93-9)

Guidance literature:

Multi-step reaction with 5 steps

1: HOBt, EDC / Ambient temperature

2: H₂ / Pd/C

3: HOBt, EDC

4: H₂ / Raney-Ni

5: Et₃N / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; nickel; In dichloromethane;

DOI:10.1016/S0960-894X(98)00238-8

Reference yield:

2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid (156130-68-6) → (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester (210481-93-9)

Guidance literature:

Multi-step reaction with 7 steps

1: EDC, DMAP / CH₂Cl₂ / 0 °C

2: HCl / ethyl acetate / 0 °C

3: HOBt, EDC / Ambient temperature

4: H₂ / Pd/C

5: HOBt, EDC

6: H₂ / Raney-Ni

7: Et₃N / CH₂Cl₂

With hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; nickel; In dichloromethane; ethyl acetate;

DOI:10.1016/S0960-894X(98)00238-8

upstream raw materials:

trifluoromethane sulfonyl chloride

(1-{(R)-1-[4-(2-Amino-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-1-methyl-ethyl)-carbamic acid tert-butyl ester

Boc-Aib-OH

1-(2-nitrophenyl)piperazine