Technology Process of (3S,5R,6R)-benzyl 6-(N-nitrobenzyloxycarbonyl-D-α-aminophenylacetamido)bisnorpenicillanate
There total 4 articles about (3S,5R,6R)-benzyl 6-(N-nitrobenzyloxycarbonyl-D-α-aminophenylacetamido)bisnorpenicillanate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 10.8 g / potassium carbonate / dimethylformamide / 24 h / Ambient temperature
2: 920 mg / potassium carbonate / benzene; dimethylformamide / 20 h / Ambient temperature
3: 1.) phosphorus pentachloride, N-methylmorpholine, 2.) toluene-p-sulphonic acid, 3.) NaHCO3 / 1.) -25 --> 0 deg C, methylene chloride, 30 min, 2.) acetone, 3.) ethyl acetate
4: 1.) triethylamine, NN-dimethylbenzylamine, methyl chloroformate / 1.) tetrahydrofuran, -10 deg C, 25 min, 2.) 2 h
With
4-methyl-morpholine; N,N'-dimethylbenzylamine; phosphorus pentachloride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; methyl chloroformate;
In
N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 920 mg / potassium carbonate / benzene; dimethylformamide / 20 h / Ambient temperature
2: 1.) phosphorus pentachloride, N-methylmorpholine, 2.) toluene-p-sulphonic acid, 3.) NaHCO3 / 1.) -25 --> 0 deg C, methylene chloride, 30 min, 2.) acetone, 3.) ethyl acetate
3: 1.) triethylamine, NN-dimethylbenzylamine, methyl chloroformate / 1.) tetrahydrofuran, -10 deg C, 25 min, 2.) 2 h
With
4-methyl-morpholine; N,N'-dimethylbenzylamine; phosphorus pentachloride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; methyl chloroformate;
In
N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) phosphorus pentachloride, N-methylmorpholine, 2.) toluene-p-sulphonic acid, 3.) NaHCO3 / 1.) -25 --> 0 deg C, methylene chloride, 30 min, 2.) acetone, 3.) ethyl acetate
2: 1.) triethylamine, NN-dimethylbenzylamine, methyl chloroformate / 1.) tetrahydrofuran, -10 deg C, 25 min, 2.) 2 h
With
4-methyl-morpholine; N,N'-dimethylbenzylamine; phosphorus pentachloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; methyl chloroformate;
