2-Amino-2-(1-methylcyclopropyl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(1-methylcyclopropyl)acetic acid
• CAS No.: 139132-43-7
• Molecular Formula: C6H11NO2
• UNII: 7L8F1EXK5G
• DSSTox Substance ID: DTXSID10973731
• Wikidata: Q27268512
• Mol file: 139132-43-7.mol

Synonyms:2-amino-2-(1-methylcyclopropyl)acetic acid;139132-43-7;7L8F1EXK5G;Glycine, N-(cyclopropylmethyl)-;(+/-)-2-(1'-Methylcyclopropyl)glycine;2-(1-Methylcyclopropyl)glycine, (+/-)-;UNII-7L8F1EXK5G;2-(1-methylcyclopropyl)-glycin;SCHEMBL17867349;DTXSID10973731;AKOS006340432;AB89128;(+/-)-2-(1-methylcyclopropyl)glycine;AMINO(1-METHYLCYCLOPROPYL)ACETIC ACID;CS-0055772;Cyclopropaneacetic acid, alpha-amino-1-methyl-;EN300-1448450;Q27268512;CYCLOPROPANEACETIC ACID, .ALPHA.-AMINO-1-METHYL-

Chemical Property of 2-Amino-2-(1-methylcyclopropyl)acetic acid

Chemical Property:

• XLogP3: -2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.078978594
• Heavy Atom Count: 9
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(CC1)C(C(=O)O)N

Technology Process of 2-Amino-2-(1-methylcyclopropyl)acetic acid

There total 6 articles about 2-Amino-2-(1-methylcyclopropyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-azido-2-(1-methylcyclopropyl)acetic acid (139132-36-8) → (+/-)-2-(1'-methylcyclopropyl)glycine (139132-43-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; for 0.75h; under 750.06 Torr;

Reference yield:

methyl 2-azido-2-(1-methylcyclopropyl)acetate (139132-22-2) → (+/-)-2-(1'-methylcyclopropyl)glycine (139132-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / KOH powdered / methanol; H₂O / 1.5 h / 65 °C

2: 94 percent / H2 / Pd/C / methanol; H2O / 0.75 h / 750.06 Torr / other 1'-substituted α-azido acids

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; water;

Reference yield:

1-methylcyclopropanecarbaldehyde (4515-89-3) → (+/-)-2-(1'-methylcyclopropyl)glycine (139132-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 4A molecular sieves / CH₂Cl₂ / 24 h

2: CH₂Cl₂ / 24 h

3: 6M HCl / 19 h / Heating

With hydrogenchloride; 4 A molecular sieve; In dichloromethane;

DOI:10.1016/0040-4020(95)01072-6

upstream raw materials:

2-azido-2-(1-methylcyclopropyl)acetic acid

1-methylcyclopropanecarbaldehyde

1-methylcyclopropanemethanol

methyl 2-azido-2-(1-methylcyclopropyl)acetate

Downstream raw materials:

(+/-)-N-benzyloxycarbonyl-2-(1'-methylcyclopropyl)glycine