cisatracurium besylate

Base Information

• Chemical Name: cisatracurium besylate
• CAS No.: 96946-54-2
• Molecular Formula: 2C₆H₅O₃S*C₅₃H₇₂N₂O₁₂
• Molecular Weight: 1243.5
• Mol file: 96946-54-2.mol

Synonyms:

Chemical Property of cisatracurium besylate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cisatracurium besylate

There total 5 articles about cisatracurium besylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine (64228-84-8) + Methyl benzenesulfonate (80-18-2) → cisatracurium besylate (64228-81-5,96946-42-8,96946-44-0,96946-46-2,96946-48-4,96946-50-8,96946-52-0,96946-54-2,96946-56-4,96946-58-6,96946-60-0)

Guidance literature:

In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 24h;

Reference yield:

N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine dioxalate (64228-78-0,64493-10-3,83285-74-9,96687-52-4,96687-53-5,110817-20-4) + Methyl benzenesulfonate (80-18-2) → cisatracurium besylate (64228-81-5,96946-42-8,96946-44-0,96946-46-2,96946-48-4,96946-50-8,96946-52-0,96946-54-2,96946-56-4,96946-58-6,96946-60-0)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; at 20 - 25 ℃; for 48h;

Reference yield:

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride (5884-22-0) → cisatracurium besylate (64228-81-5,96946-42-8,96946-44-0,96946-46-2,96946-48-4,96946-50-8,96946-52-0,96946-54-2,96946-56-4,96946-58-6,96946-60-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; zinc(II) chloride; (2S,3S)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid / tetrahydrofuran / 21 h / 20 °C / Inert atmosphere; Reflux

2.1: acetic acid / toluene / 4 h / 80 °C

2.2: 1 h / 20 °C

3.1: sodium hydroxide / water; dichloromethane / 0.25 h / 20 °C / pH 9 - 10

3.2: 2 h / 8 - 12 °C / 760.05 Torr

4.1: acetic acid; cobalt(II) chloride hexahydrate / acetonitrile / 12 h / 60 °C

5.1: dichloromethane; dimethyl sulfoxide / 24 h / 20 °C

With sodium tetrahydroborate; (2S,3S)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid; cobalt(II) chloride hexahydrate; acetic acid; sodium hydroxide; zinc(II) chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;

upstream raw materials:

N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine dioxalate

Methyl benzenesulfonate

N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-diyl-bis-(R)-(-)-tetrahydropapaverine

1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3.4-dihydroisoquinoline hydrochloride