Cycloheximide

Base Information

Chemical Name:Cycloheximide
CAS No.:4630-75-5
Deprecated CAS:17974-04-8,4630-76-6,6399-67-3
Molecular Formula:C₁₅H₂₃NO₄
Molecular Weight:281.352
Hs Code.:
European Community (EC) Number:200-636-0
ICSC Number:0244
NSC Number:758187,185
UN Number:2588
UNII:98600C0908
DSSTox Substance ID:DTXSID6024882
Nikkaji Number:J107.994H
Wikipedia:Cycloheximide
Wikidata:Q412895
NCI Thesaurus Code:C171712
Pharos Ligand ID:LJHWJX8XBGWD
Metabolomics Workbench ID:51400
ChEMBL ID:CHEMBL123292

Synonyms:Actidione;Cicloheximide;Cycloheximide

Suppliers and Price of Cycloheximide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Cycloheximide

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:281.16270821
Heavy Atom Count:20
Complexity:404
Transport DOT Label:Poison

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Chemical Classes:Pesticides -> Plant Growth Regulators
Canonical SMILES:CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
Isomeric SMILES:C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
Inhalation Risk:Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
Effects of Short Term Exposure:The substance is irritating to the eyes and skin. Exposure could cause death.

Technology Process of Cycloheximide

There total 7 articles about Cycloheximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3428-71-5,15676-38-7
C₁₆H₂₆N₄O₄

: 66-81-9,642-81-9,1154-57-0,3226-22-0,4630-75-5,5549-69-9,6258-25-9,6746-42-5,17280-60-3,17973-87-4,18006-33-2,29106-61-4,94130-62-8,94130-63-9,94799-82-3,95272-16-5,95272-17-6,95272-18-7
4-[(S)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione

Guidance literature:: With acetic acid; sodium nitrite; In water; at 0 ℃; for 0.25h; pH=5;
DOI:10.1016/S0040-4020(01)91400-0

Reference yield:

: 2066-88-8
(2,6-dioxo-piperidin-4-yl)-acetaldehyde

: 93921-42-7
(+)-(2S,4R)-trans-2,4-dimethyl-1-cyclohexanone

: 94130-63-9
(2S,4S,6R,αS)-cycloheximide

: 66-81-9,642-81-9,1154-57-0,3226-22-0,4630-75-5,5549-69-9,6258-25-9,6746-42-5,17280-60-3,17973-87-4,18006-33-2,29106-61-4,94130-62-8,94130-63-9,94799-82-3,95272-16-5,95272-17-6,95272-18-7
(2S,4S,6S,αS)-cycloheximide

: 642-81-9
Cycloheximide

: 66-81-9
Cycloheximide

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h; Yield given. Yields of byproduct given;
DOI:10.1271/bbb1961.48.2315

Reference yield:

: 2066-88-8
(2,6-dioxo-piperidin-4-yl)-acetaldehyde

: ((4R,6S)-4,6-Dimethyl-cyclohex-1-enyloxy)-trimethyl-silane

: 94130-63-9
(2S,4S,6R,αS)-cycloheximide

: 66-81-9,642-81-9,1154-57-0,3226-22-0,4630-75-5,5549-69-9,6258-25-9,6746-42-5,17280-60-3,17973-87-4,18006-33-2,29106-61-4,94130-62-8,94130-63-9,94799-82-3,95272-16-5,95272-17-6,95272-18-7
(2S,4S,6S,αS)-cycloheximide

: 642-81-9
Cycloheximide

: 66-81-9
Cycloheximide

Guidance literature:: With titanium tetrachloride; In dichloromethane; Yield given. Yields of byproduct given; 1.) 20 deg C, 5 min, 2.) -45 deg C, 5 min;
DOI:10.1271/bbb1961.48.2315