5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide

Base Information

• Chemical Name: 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide
• CAS No.: 121949-63-1
• Molecular Formula: C₃₂H₃₂BrNO₅
• Molecular Weight: 590.514
• Mol file: 121949-63-1.mol

Synonyms:

Chemical Property of 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide

There total 5 articles about 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(3-benzyloxy-2,4-dimethoxyphenyl)ethylamine (21882-90-6) + 5-benzyloxy-2-bromophenylacetic acid (64434-24-8) → 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide (121949-63-1)

Guidance literature:

at 140 - 150 ℃; for 0.5h;

DOI:10.1002/jhet.5570250557

Reference yield:

3-(benzyloxy)-2,4-dimethoxybenzaldehyde (20321-46-4) → 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide (121949-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature

2: 92 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

3: 90 percent / 0.5 h / 140 - 150 °C

With lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; In tetrahydrofuran;

DOI:10.1002/jhet.5570250557

Reference yield:

3-hydroxy-2,4-dimethoxy benzaldehyde (32246-34-7) → 5-benzyloxy-N-<2-(3'-benzyloxy-2',4'-dimethoxyphenyl)ethyl>-2-bromophenylacetamide (121949-63-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / Na₂CO₃ / ethanol / 24 h / Heating

2: 87 percent / methylamine hydrochloride, anhydrous sodium acetate / 16 h / Ambient temperature

3: 92 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

4: 90 percent / 0.5 h / 140 - 150 °C

With lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570250557

upstream raw materials:

2-(3-benzyloxy-2,4-dimethoxyphenyl)ethylamine

5-benzyloxy-2-bromophenylacetic acid

3-(benzyloxy)-2,4-dimethoxybenzaldehyde

3-hydroxy-2,4-dimethoxy benzaldehyde

Downstream raw materials:

1-(5'-benzyloxy-2'-bromobenzylidene)-6-benzyloxy-2-carbethoxy-5,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

1-(2'-bromo-5'-hydroxybenzyl)-5,7-dimethoxy-6-hydroxy-3,4-dihydroisoquinoline hydrochloride

1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-5,7-dimethoxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline

6-benzyloxy-1-(5'-benzyloxy-2'-bromobenzyl)-5,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

Refernces