Technology Process of (S)-1-phenylethyl (+)-2-(3-indolyl)propionate
There total 5 articles about (S)-1-phenylethyl (+)-2-(3-indolyl)propionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
at 25 ℃;
for 5h;
DOI:10.1271/bbb.65.270
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethyl ether
2.1: 2.73 g / benzyltriethylammonium bromide; 30 percent NaOH / CH2Cl2 / 1 h / 0 °C
3.1: LDA / tetrahydrofuran / 1 h / -78 °C
3.2: 90.8 percent / tetrahydrofuran / 2 h / -78 °C
4.1: 91.2 percent / KOH / methanol; H2O / 1 h / 70 °C
5.1: DCC; DMAP / CH2Cl2 / 5 h / 25 °C
With
dmap; potassium hydroxide; sodium hydroxide; benzyltriethylammonium bromide; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1271/bbb.65.270
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2.73 g / benzyltriethylammonium bromide; 30 percent NaOH / CH2Cl2 / 1 h / 0 °C
2.1: LDA / tetrahydrofuran / 1 h / -78 °C
2.2: 90.8 percent / tetrahydrofuran / 2 h / -78 °C
3.1: 91.2 percent / KOH / methanol; H2O / 1 h / 70 °C
4.1: DCC; DMAP / CH2Cl2 / 5 h / 25 °C
With
dmap; potassium hydroxide; sodium hydroxide; benzyltriethylammonium bromide; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1271/bbb.65.270
