2597-26-4

Usage

Uses

Used in Agriculture and Horticulture:
1H-Indole-3-acetic acid, .alpha.-Methylis used as a plant growth regulator for promoting root development in cuttings and seedlings. It stimulates root formation and shoot growth in a variety of plants, leading to improved plant establishment and overall growth.
1H-Indole-3-acetic acid, .alpha.-Methylis also used to increase the yield and quality of fruits and vegetables. By influencing plant growth and development processes, it can enhance the production of desirable traits in crops, such as larger fruits, improved flavor, and longer shelf life.
Used in Biotechnology:
1H-Indole-3-acetic acid, .alpha.-Methylhas potential applications in biotechnology for the production of transgenic plants with improved growth and stress tolerance traits. By incorporating 1H-Indole-3-acetic acid, .alpha.-Methyl- into the genetic makeup of plants, scientists can develop new plant varieties that are more resilient to environmental stressors, such as drought, salinity, and extreme temperatures. This can lead to increased crop yields and improved food security in challenging growing conditions.

Upstream product

• 120-72-9 indole 
• 78-97-7 2-hydroxy-propionitrile 
• 3389-21-7 3-(2-bromoethyl)-1H-indole 
• 124-38-9 carbon dioxide 
• 152905-99-2 Diethyl α-methyl-2-(ethoxycarbonyl)-2-indolemalonate 
• 3770-50-1 2-carbethoxyindole 
• 174319-54-1 methyl 3-(2-methoxy-2-oxoethyl)-1H-indole-1-carboxylate 
• 1912-33-0 Indole-3-acetic acid methyl ester 
• 87-51-4 indole-3-acetic acid 
• 778-82-5 ethyl 3-indoleacetate 
• 10006-91-4 ethyl 2-(1H-indol-3-yl)-propionate 
• 338744-37-9 α-methyl-1-methoxycarbonyl-3-indoleacetic acid methyl ester 
• 152906-03-1 α-Methyl-2-carboxy-3-indoleacetic acid 
• 35643-98-2 2-methyl-4-oxo-butyric acid 

Downstream Products

• 21299-80-9 (2R)-(3-Indolyl)propionic acid 
• 126979-07-5 4-Methyl-1-phenylpyrano<3,4-b>indol-3-one 
• 126979-08-6 1-<1-(Indol-3-yl)ethyl>-4-methylpyrano<3,4-b>indol-3-one 
• 10006-92-5 (2R)-(-)-2-(3-indolyl)-propan-1-ol 
• 21070-37-1 (S)-(+)-α-methyl-3-indolylacetic acid 
• 141071-79-6 3-(1-Benzylindol-3-yl)propionic Acid 
• 125537-93-1 acremoauxin A 
• 104970-90-3 5,11-dimethyl-1,4-diphenyl-6H-pyridazo<4,5-b>carbazole 
• 94193-98-3 2,3-dibenzoyl-1,4-dimethyl-9H-carbazole 
• 738608-57-6 2-(2-benzoyl-1H-indol-3-yl)-pentan-3-one 
• 338744-39-1 (S)-1-phenylethyl (+)-2-(3-indolyl)propionate 
• 338744-40-4 (R)-1-phenylethyl (-)-2-(3-indolyl)propionate 

Relevant academic research and scientific papers

Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.

CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6)

The invention relates to compounds which are suitable for the treatment of a disease associated with kallikrein-like peptidase 6 overexpression and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds or pharmaceutical compositions.

Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives

A new route to substituted β-carbolines and carbazoles is described. Diketoindole intermediates, prepared by Friedel-Crafts acylations of 3-substituted indoles, have been converted to 3-hydroxycarbazoles and β-carbolines in good yields, 51-96% and 82-97%, respectively. This method also allows for the formation of 4-substituted β-carbolines. The application of this methodology to the synthesis of the natural products hyellazole and 6-chlorohyellazole is also described.

Synthesis, absolute configuration and biological activity of both enantiomers of 2-(5,6-dichloro-3-indolyl)propionic acid: New dichloroindole auxins

Racemic 2-(5,6-dichloro-3-indolyl)propionic acid (5,6-Cl2-2-IPA) was synthesized from 5,6-dichloroindole-3-acetic acid (5,6-Cl2-IAA) by successive esterification, methoxycarbonylation, methylation, and double hydrolysis. The racemate was converted to the diastereomeric esters of (S)-(-)-1-phenylethyl alcohol. These were separated by HPLC into two optically active diastereomers and then hydrolyzed with p-TsOH to the optically active enantiomers of 5,6-Cl2-Z-IPA. The absolute configurations of both the 5,6-CI2-Z-IPA enantiomers were determined by comparing the 1H-NMR spectra of their diastereomeric (S)-(-)-1-phenylethyl esters with those of the diastereomeric (S)-(-)-1-phenylethyl esters of 2-(3-indolyl)propionic acid (2-IPA) whose absolute configurations are already known. There was no essential difference between (S)-(+)- and (R)-(-)-5,6-Cl2-2-IPA in hypocotyl growth-inhibiting activity toward Chinese cabbage, but their inhibitory activities were stronger than that of the potent mother auxin, 5,6-Cl2-IAA. No essential difference in the coleoptile elongating activity of Avena sativa was apparent for the enantiomers, this activity being about one-third that of 5,6-Cl2-IAA.