N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Base Information

Chemical Name:N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester
CAS No.:864531-10-2
Molecular Formula:C₄₆H₆₈N₄O₁₁
Molecular Weight:853.066
Hs Code.:

<i>N</i>-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid <i>tert</i>-butyl ester

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Chemical Property of N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

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Technology Process of N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

There total 3 articles about N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 111-64-8
n-octanoic acid chloride

: 778591-23-4
tert-butyl 4-((3-((benzoyloxy)amino)propyl)amino)-2-(2-((3-((benzoyloxy)amino)propyl)amino)-2-oxoethyl)-2-hydroxy-4-oxobutanoate

: 864531-10-2
N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: In dichloromethane; for 1h; Heating;
DOI:10.1016/j.bmcl.2005.05.114

Reference yield:

: 198217-06-0
N^α-benzoyloxy-3-(tert-butoxycarbonylamino)propylamine

: 864531-10-2
N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl

2.1: HOSu; DCC / dioxane

2.2: TEA / acetonitrile

3.1: 80 percent / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.114

Reference yield:

: 1-N-benzoyloxy-1,3-diaminopropane dihydrochloride

: 864531-10-2
N-[3-(benzoyloxy-octanoyl-amino)-propyl]-2-{[3-(benzoyloxy-octanoyl-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOSu; DCC / dioxane

1.2: TEA / acetonitrile

2.1: 80 percent / CH₂Cl₂ / 1 h / Heating

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.114