5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione
CAS No.:592527-68-9
Molecular Formula:C₂₇H₄₀F₄N₄O₄Si
Molecular Weight:588.718
Hs Code.:

5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1<i>H</i>-pyrimidine-2,4-dione

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Chemical Property of 5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

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Technology Process of 5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

There total 5 articles about 5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4212-49-1
5-ethyluracil

: 592527-68-9
5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethyldisilazane; ammonium sulfate / Heating

1.2: 25 °C

2.1: K₂CO₃ / dimethylformamide

3.1: K₂CO₃; NaI / acetonitrile / Heating

With ammonium sulfate; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 592527-68-9
5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Cs₂CO₃; NMP

2: Nickel boride; aq. HCl / methanol / 60 °C

3: K₂CO₃ / bis-(2-methoxy-ethyl) ether / 220 °C

4: K₂CO₃; NaI / acetonitrile / Heating

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; nickel boride; potassium carbonate; caesium carbonate; sodium iodide; In methanol; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 186386-90-3
4-fluoro-2-(2,2,2-trifluoroethoxy)aniline

: 592527-68-9
5-ethyl-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / bis-(2-methoxy-ethyl) ether / 220 °C

2: K₂CO₃; NaI / acetonitrile / Heating

With potassium carbonate; sodium iodide; In diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1016/S0960-894X(03)00305-6