2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

Base Information

Chemical Name:2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid
CAS No.:133933-17-2
Molecular Formula:C₂₆H₂₆N₄O₆
Molecular Weight:490.516
Hs Code.:

2-desamino-2-methyl-N<sup>10</sup>-propargyl-5,8-dideazahomofolic acid

Synonyms:

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Chemical Property of 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

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Technology Process of 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

There total 7 articles about 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(4-{[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-methyl}-benzoylamino)-pentanedioic acid diethyl ester

: 133933-17-2
2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

Guidance literature:: With sodium hydroxide; In acetonitrile; for 18h; Yield given; Ambient temperature;
DOI:10.1021/jm00113a011

Reference yield:

: 16450-41-2
L-glutamic acid diethyl ester

: 133933-17-2
2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide (DCC), pyridine / 65 h / 25 °C

2: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

With pyridine; sodium hydroxide; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1021/jm00113a011

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 133933-17-2
2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazahomofolic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 17 percent / K₂CO₃ / methanol / 3 h / Heating

2: MgO / N,N-dimethyl-acetamide / 18 h / 90 - 100 °C

3: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

4: dicyclohexylcarbodiimide (DCC), pyridine / 65 h / 25 °C

5: 0.1 N aq. NaOH / acetonitrile / 18 h / Ambient temperature

With pyridine; sodium hydroxide; magnesium oxide; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm00113a011