*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate
• CAS No.: 101250-25-3
• Molecular Formula: C₂₁H₃₀N₂O₇S
• Molecular Weight: 454.544

Synonyms:

Chemical Property of *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate

There total 5 articles about *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(2-Methylpropyl)-aziridine (23852-57-5) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-25-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 55 percent / H₂S / ethanol / -78 - 25 °C

2: 43 percent / NH₃ liquid

3: 77 percent / 1H-benzotriazol-1-ol (HOBT), DCC / 72 h / 0 °C

4: m-chloroperoxybenzoic acid / CHCl₃ / 24 h / Heating

5: trifluoroacetic acid (TFA)

With hydrogen sulfide; ammonia; benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; chloroform;

DOI:10.1021/jm00156a012

Reference yield:

(S)-2-amino-4-methyl-1-pentanethiol (88264-65-7) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 43 percent / NH₃ liquid

2: 77 percent / 1H-benzotriazol-1-ol (HOBT), DCC / 72 h / 0 °C

3: m-chloroperoxybenzoic acid / CHCl₃ / 24 h / Heating

4: trifluoroacetic acid (TFA)

With ammonia; benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In chloroform;

DOI:10.1021/jm00156a012

Reference yield:

(S)-1,1-dimethylethyl <(2-amino-4-methylpentyl)thio>acetate (101250-59-3) → *,R*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate (101250-25-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / 1H-benzotriazol-1-ol (HOBT), DCC / 72 h / 0 °C

2: m-chloroperoxybenzoic acid / CHCl₃ / 24 h / Heating

3: trifluoroacetic acid (TFA)

With benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In chloroform;

DOI:10.1021/jm00156a012

upstream raw materials:

(S)-2-((S)-1-tert-Butoxycarbonylmethanesulfonylmethyl-3-methyl-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester

(S)-2-(2-Methylpropyl)-aziridine

(S)-2-amino-4-methyl-1-pentanethiol

(S)-1,1-dimethylethyl <(2-amino-4-methylpentyl)thio>acetate

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