benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

Base Information

Chemical Name:benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate
CAS No.:1352133-76-6
Molecular Formula:C₁₉H₂₇F₂NO₄
Molecular Weight:371.424
Hs Code.:

Synonyms:

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Chemical Property of benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

Chemical Property:

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Technology Process of benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

There total 6 articles about benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352133-74-4
methyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

: 1352133-76-6
benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

1.2: 0 °C / Cooling with ice

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 12 h / 20 °C

With caesium carbonate; lithium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: 111060-65-2
(S)-2-(dibenzylamino)-4-methylpentanal

: 1352133-76-6
benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hexane; water / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 12 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C / Inert atmosphere

4.1: diethylamino-sulfur trifluoride / dichloromethane / 6 h / 20 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

6.2: 0 °C / Cooling with ice

7.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

7.2: 12 h / 20 °C

With hydrogenchloride; oxalyl dichloride; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; dimethyl sulfoxide; lithium hydroxide; In methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: (S)-3-Dibenzylamino-5-methyl-2-oxo-hexanoic acid methyl ester

: 1352133-76-6
benzyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 6 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

3.2: 0 °C / Cooling with ice

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h / 20 °C

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340