C₁₅H₂₁NO₇

Base Information

Chemical Name:C₁₅H₂₁NO₇
CAS No.:1246616-75-0
Molecular Formula:C₁₅H₂₁NO₇
Molecular Weight:327.334
Hs Code.:

C<sub>15</sub>H<sub>21</sub>NO<sub>7</sub>

Synonyms:

Suppliers and Price of C₁₅H₂₁NO₇

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylicAcid2,5-DiethylEster
10mg
$ 90.00

TRC
1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylicAcid2,5-DiethylEster
5mg
$ 55.00

Total 1 raw suppliers

Chemical Property of C₁₅H₂₁NO₇

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylicAcid2,5-DiethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-(2,2-Dimethoxyethyl)-1,4-dihydro-4-oxo-2,5-pyridinedicarboxylic Acid 2,5-Diethyl Ester is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Technology Process of C₁₅H₂₁NO₇

There total 3 articles about C₁₅H₂₁NO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1246616-74-9
diethyl 4-oxo-4H-pyran-2,5-dicarboxylate

: 22483-09-6
2,2-dimethoxyethylamine

: 1246616-75-0
C₁₅H₂₁NO₇

Guidance literature:: In ethanol; at 0 - 20 ℃; for 16h;

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1246616-75-0
C₁₅H₂₁NO₇

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 4 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

2.2: 0.33 h

3.1: ethanol / 16 h / 0 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield:

: 134653-70-6,51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

: 1246616-75-0
C₁₅H₂₁NO₇

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

1.2: 0.33 h

2.1: ethanol / 16 h / 0 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;