Ethyl (1R,2R)-2-AMinocyclopentanecarboxylate

Base Information

• Chemical Name: Ethyl (1R,2R)-2-AMinocyclopentanecarboxylate
• CAS No.: 1609100-30-2
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Mol file: 1609100-30-2.mol

Synonyms:

Chemical Property of Ethyl (1R,2R)-2-AMinocyclopentanecarboxylate

Chemical Property:

• Boiling Point: 213.4±33.0 °C(Predicted)
• PKA: 10.10±0.40(Predicted)
• Density: 1.045±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl (1R,2R)-2-AMinocyclopentanecarboxylate

There total 39 articles about Ethyl (1R,2R)-2-AMinocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cis-ethyl 2-(benzylamino)cyclopentanecarboxylate (158262-07-8) → cis-ethyl 2-aminocyclopentanecarboxylate (1609100-30-2,752181-59-2)

Guidance literature:

With hydrogen; palladium on carbon; In ethanol; for 22h; under 2327.23 Torr;

Reference yield: 80.0%

trans-ethyl 2-((4-methoxyphenyl)amino)cyclopentanecarboxylate → trans-ethyl 2-aminocyclopentanecarboxylate (1609100-30-2,752181-59-2)

Guidance literature:

With ammonium cerium (IV) nitrate; sulfuric acid; In water; acetonitrile; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.15.48

Reference yield: 79.0%

ethyl 2-((4-methoxyphenyl)amino)cyclopentanecarboxylate → ethyl cis-2-amino-1-cyclopentane-carboxylate (38052-23-2,114745-45-8,114745-46-9,1609100-30-2,752181-59-2)

Guidance literature:

With ammonium cerium (IV) nitrate; sulfuric acid; In water; acetonitrile; at 0 ℃; for 1h;

DOI:10.1021/acs.orglett.8b00904

upstream raw materials:

2-aza-3-oxobicyclo<3.2.0>heptane

ethanol

2-benzylamino-cyclopentanecarboxylic acid ethyl ester

ethyl 2-amino-1-cyclopentene-1-carboxylate

Downstream raw materials:

ethyl (1R,2S)-2-aminocyclopentane-1-carboxylate

cis-2-amino-1-cyclopentanecarboxamide

trans-2-aminocyclopentanecarboxamide

ethyl cis-2-isothiocyanato-1-cyclopentanecarboxylate