Technology Process of (1'R,3R)-3-Hydroxy-3-phenylpropansaeure-(2-hydroxy-1,2,2-triphenylethyl)ester
There total 13 articles about (1'R,3R)-3-Hydroxy-3-phenylpropansaeure-(2-hydroxy-1,2,2-triphenylethyl)ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 1.) LDA / 1.) THF, 0 deg C, 30 min; 2.) -78 deg C, 1 h
With
pyridine; lithium diisopropyl amide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h
2: 90 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature
3: 1.) LDA / 1.) THF, 0 deg C, 30 min; 2.) -78 deg C, 1 h
With
pyridine; iodine; magnesium; lithium diisopropyl amide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
2: pyridine / CH2Cl2 / 0 °C
3: lithium diisopropylamide / tetrahydrofuran / -78 deg C to O deg C
4: 1) magnesium bromide / in dimethyl ether and THF, 1) -78 deg C, 1 h 2) -115 deg C 40 min
With
pyridine; magnesium bromide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(01)91110-4
