(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

Base Information

Chemical Name:(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide
CAS No.:1603845-56-2
Molecular Formula:C₄₂H₅₄N₈O₃
Molecular Weight:718.943
Hs Code.:

(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

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Chemical Property of (R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

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Technology Process of (R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

There total 11 articles about (R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1603845-41-5
C₄₉H₆₆N₈O₆

: 79-03-8
propionyl chloride

: 1603845-56-2
(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

Guidance literature:: C₄₉H₆₆N₈O₆; propionyl chloride;

In dichloromethane;

Reference yield:

: 2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin

: 1603845-56-2
(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

Guidance literature:: Multi-step reaction with 11 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 14 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 80 °C

4: potassium carbonate

5: trifluoroacetic acid / dichloromethane

6: potassium carbonate / N,N-dimethyl-formamide / 80 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

9: dmap

10: hydrogen

With dmap; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1603845-56-2
(R)-4-(1-adamantanyl)-N-(2-(4-(4-amino-3-(4-phenoxy-3-propionamidophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethyl)-2-methylbutanamide

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 80 °C

3: potassium carbonate

4: trifluoroacetic acid / dichloromethane

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

8: dmap

9: hydrogen

With dmap; bis-triphenylphosphine-palladium(II) chloride; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;