5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

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Chemical Name:5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine
CAS No.:1260248-04-1
Molecular Formula:C₂₅H₂₂N₆O
Molecular Weight:422.489
Hs Code.:

Synonyms:

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Chemical Property of 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

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Technology Process of 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

There total 6 articles about 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74402-57-6
methyl 3-cyanopyrazine-2-carboxylate

: 1260248-03-0
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

: 1260248-04-1
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 3 h / Inert atmosphere

1.2: 1.33 h / -78 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 72 h / 60 °C

2.2: 0.17 h / 20 °C

3.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere

3.2: -20 - 20 °C

3.3: 1 h

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Dimethyl ether; ethanol; water / 0.42 h / 140 °C / Microwave irradiation

5.1: Chiralpak IA column / n-heptane; ethanol; 2,2'-iminobis[ethanol] / Resolution of racemate

With caesium carbonate; magnesium; lithium chloride; titanium(IV) tetraethanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; Dimethyl ether; n-heptane; water; 2,2'-iminobis[ethanol];

Reference yield:

: 67367-37-7
3-amidecarbonylpyrazine-2-carboxylic acid

: 1260248-03-0
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

: 1260248-04-1
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 3 h / Inert atmosphere

2.2: 1.33 h / -78 °C

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 72 h / 60 °C

3.2: 0.17 h / 20 °C

4.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere

4.2: -20 - 20 °C

4.3: 1 h

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Dimethyl ether; ethanol; water / 0.42 h / 140 °C / Microwave irradiation

6.1: Chiralpak IA column / n-heptane; ethanol; 2,2'-iminobis[ethanol] / Resolution of racemate

With caesium carbonate; magnesium; triethylamine; lithium chloride; titanium(IV) tetraethanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; Dimethyl ether; n-heptane; dichloromethane; water; 2,2'-iminobis[ethanol];

Reference yield:

: 1260248-25-6
3-(4-methoxy-3,5-dimethylbenzoyl)pyrazine-2-carbonitrile

: 1260248-03-0
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

: 1260248-04-1
5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 72 h / 60 °C

1.2: 0.17 h / 20 °C

2.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 1.5 h / Inert atmosphere

2.2: -20 - 20 °C

2.3: 1 h

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Dimethyl ether; ethanol; water / 0.42 h / 140 °C / Microwave irradiation

4.1: Chiralpak IA column / n-heptane; ethanol; 2,2'-iminobis[ethanol] / Resolution of racemate

With caesium carbonate; magnesium; lithium chloride; titanium(IV) tetraethanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; Dimethyl ether; n-heptane; water; 2,2'-iminobis[ethanol];