74402-57-6

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 770-00-3 methylester of pyrazinecarboxylic acid 4-oxide 
• 67367-37-7 3-amidecarbonylpyrazine-2-carboxylic acid 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1260248-28-9 3-(3-bromobenzoyl)pyrazine-2-carbonitrile 
• 1260248-25-6 3-(4-methoxy-3,5-dimethylbenzoyl)pyrazine-2-carbonitrile 
• 1260248-33-6 3-(3-fluoro-4-methoxybenzoyl)pyrazine-2-carbonitrile 
• 1260248-03-0 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-04-1 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-30-3 (R)-5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-31-4 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-02-9 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrimidin-5-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-06-3 5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-21-2 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(pyrazin-2-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-24-5 (S)-5-(4-methoxy-3,5-dimethylphenyl)-5-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-26-7 N-((3-cyanopyrazin-2-yl)(4-methoxy-3,5-dimethylphenyl)methylene)-2-methylpropane-2-sulfinamide 
• 1260248-27-8 5-(3-bromophenyl)-5-(4-methoxy-3,5-dimethylphenyl)-5H-pyrrolo[3,4-b]pyrazin-7-amine 
• 1260248-29-0 N-((3-bromophenyl)(3-cyanopyrazin-2-yl)methylene)-2-methylpropane-2-sulfinamide 

Relevant academic research and scientific papers

Conformational studies of new pseudotripeptide with pyrazine amidoxime motif and simplified analogs using IR, NMR spectroscopy, and molecular dynamic simulations

Solution structures of new pyrazine-based pseudotripeptide with amidoxime function and simplified pseudodipeptide analogs were determined by a combination of IR and NMR spectroscopic studies and molecular dynamic simulations using explicit chloroform as a

Synthesis and conformational study of novel pyrazine-based pseudopeptides bearing amidoxime, amidoxime ester and 1,2,4-oxadiazole units

An efficient synthesis of pyrazine-based amidoximes bearing amino acid residues is reported. Esterification of amidoximes with further microwave-assisted cyclization into α-amino acid-derived 1,2,4-oxadiazoles has been developed. Conformational analysis o

5H-PYRROLO[3,4-￡>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE

The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β- amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines

Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.