DEF-K-ADE

Base Information

• Chemical Name: DEF-K-ADE
• CAS No.: 1360788-59-5
• Molecular Formula: C₃₆H₅₂N₈O₁₆
• Molecular Weight: 852.853
• Mol file: 1360788-59-5.mol

Synonyms:

Chemical Property of DEF-K-ADE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DEF-K-ADE

There total 2 articles about DEF-K-ADE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DEF-(CEL)-ADE (1360788-58-4) → DEF-K-ADE (1360788-59-5)

Guidance literature:

With C-terminal domain of wild type MnmC; water; oxygen; flavin adenine dinucleotide; In aq. buffer; at 20 ℃; for 18h; pH=8; Enzymatic reaction;

DOI:10.1002/cbic.201900158

Reference yield:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Glu(OtBu)-OH (71989-18-9) + (S)-6-[(Diphenyl-p-tolyl-methyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid → DEF-K-ADE (1360788-59-5)

Guidance literature:

Fmoc-Glu(OtBu)-OH; With benzotriazol-1-ol; diisopropyl-carbodiimide; at 20 ℃; for 1.16667h; solid phase reaction;

With piperidine; solid phase reaction;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-Fmoc L-Phe; Fmoc-(tBu)Asp-OH; Fmoc-Glu(OtBu)-OH; (S)-6-[(Diphenyl-p-tolyl-methyl)-amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid; Further stages;

DOI:10.1016/j.str.2011.02.013

upstream raw materials:

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

N-Fmoc L-Phe

Fmoc-(tBu)Asp-OH

Fmoc-Glu(OtBu)-OH