Technology Process of (+/-)-6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)-N-(2H-tetrazol-5-yl)nicotinamide
There total 7 articles about (+/-)-6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)-N-(2H-tetrazol-5-yl)nicotinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / palladium diacetate / 1,2-dimethoxyethane; water / 30 - 50 °C
2.1: tetrahydrofuran / 90 °C / Molecular sieve
3.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 2 h / 0 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 80 °C
5.2: 80 °C
With
water; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; zinc(II) chloride; lithium hydroxide;
palladium diacetate;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / palladium diacetate / 1,2-dimethoxyethane; water / 30 - 50 °C
2.1: tetrahydrofuran / 90 °C / Molecular sieve
3.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 2 h / 0 °C
4.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 80 °C
5.2: 80 °C
With
water; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; zinc(II) chloride; lithium hydroxide;
palladium diacetate;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / 1,2-dimethoxyethane / 5 h / 120 °C / Molecular sieve; Sealed tube
2.1: sodium cyanoborohydride; acetic acid; methanol / 1,2-dimethoxyethane / 20 °C
3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 80 °C
4.2: 80 °C
With
methanol; water; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium hydroxide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
