57688-34-3

Basic information

• Product Name: 4'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE
• Synonyms: AKOS BAR-0143;4-AMINO-4'-TRIFLUOROMETHYLDIPHENYL;4'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-AMINE;4-Amino-4''-(trifluoromethyl)-biphenyl;4-[4-(Trifluoromethyl)phenyl]aniline;4'-(TrifluoroMethyl)-biphenyl-4-aMine
• CAS NO: 57688-34-3
• Molecular Formula: C₁₃H₁₀F₃N
• Molecular Weight: 237.22
• Mol File: 57688-34-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 303.1 °C at 760 mmHg
• Flash Point: 134.6 °C
• Appearance: /
• Density: 1.245g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.90±0.10(Predicted)
• CAS DataBase Reference: 4'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(57688-34-3)
• EPA Substance Registry System: 4'-TRIFLUOROMETHYL-BIPHENYL-4-YLAMINE(57688-34-3)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 57688-34-3(Hazardous Substances Data)

Usage

General Description

4'-Trifluoromethyl-biphenyl-4-ylamine is an organic compound with the formula C13H10F3N. It is a member of the biphenyl-4-ylamine family of chemicals, which are commonly used as intermediates in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This particular compound is characterized by the presence of a trifluoromethyl group and a biphenyl backbone, which confer unique chemical and physical properties. It can be used as a building block in the synthesis of various biologically active molecules, and it is also employed as a ligand in catalytic reactions. Its stable nature and its ability to participate in diverse chemical reactions make it a valuable tool for organic chemists and a versatile component in the production of numerous industrial and research chemicals.

Upstream product

• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 106-40-1 4-bromo-aniline 
• 146741-82-4 4-chloro-4′-(trifluoromethyl)-1,1′-biphenyl 
• 80460-73-7 (4-aminophenyl)boronic acid hydrochloride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 106-47-8 4-chloro-aniline 
• 540-37-4 p-aminoiodobenzene 
• 1130440-65-1 [4-(trifluoromethyl)phenyl](triphenylphosphine)gold(I) 
• 586-78-7 para-nitrophenyl bromide 
• 80245-34-7 4-nitro-4’-(trifluoromethyl)biphenyl 

Downstream Products

• 858105-10-9 N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide 
• 1364791-76-3 4-benzyloxy-N-[4'-(trifluoromethyl)biphenyl-4-yl]-1,2,5-oxadiazole-3-carboxamide 
• 1552318-77-0 C₂₂H₁₆F₃NO₂ 
• 1552318-79-2 C₂₇H₂₃F₃N₂O₄ 
• 1592729-77-5 C₂₄H₁₈F₃NO₃ 
• 1552318-78-1 C₂₅H₂₀F₃NO₃ 
• 1383800-00-7 methyl 6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)nicotinate 
• 1383800-31-4 6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)nicotinic acid 
• 1383800-34-7 (+/-)-6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)-N-(2H-tetrazol-5-yl)nicotinamide 
• 1383800-28-9 (+/-)-N-((1H-tetrazol-5-yl)methyl)-6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-ylamino)butyl)nicotinamide 
• 1357113-87-1 N-(4'-trifluoromethylbiphenyl)-2,3-naphthimide 
• 1357113-86-0 N-(4'-trifluoromethylbiphenyl)phthalimide 

Relevant articles and documents

Discovery of Biphenyl-Sulfonamides as Novel β- N-Acetyl- d -Hexosaminidase Inhibitors via Structure-Based Virtual Screening

Novel insecticidal targets are always in demand due to the development of resistance. OfHex1, a β-N-acetyl-d-hexosaminidase identified in Ostrinia furnacalis (Asian corn borer), is involved in insect chitin catabolism and has proven an ideal target for insecticide development. In this study, structure-based virtual screening, structure simplification, and biological evaluation are used to show that compounds with a biphenyl-sulfonamide skeleton have great potential as OfHex1 inhibitors. Specifically, compounds 10k, 10u, and 10v have Ki values of 4.30, 3.72, and 4.56 μM, respectively, and thus, they are more potent than some reported nonglycosyl-based inhibitors such as phlegmacin B1 (Ki = 26 μM), berberine (Ki = 12 μM), 2 (Ki = 11.2 μM), and 3 (Ki = 28.9 μM). Furthermore, inhibitory kinetic assessments reveal that the target compounds are competitive inhibitors with respect substrate, and based on toxicity predictions, most of them have potent drug properties. The obtained results indicate that the biphenyl-sulfonamide skeleton characterized by simple chemical structure, synthetic tractability, potent activity, and low toxicity has potential for further development in pest management targeting OfHex1.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

A terphenyl structure containing between the diamine compound and its synthetic method and application

The invention discloses a diamine compound with a meta-terphenyl structure as well as a synthetic method and application thereof. An amino group is introduced by using an aryl halide through Suzuki reaction, and the functional diamine compound with the meta-terphenyl structure is obtained by virtue of bromination, diazotization, Suzuki coupling and reduction. The synthetic method for the diamine compound is simple and relatively high in yield, and the synthesized compound has certain fluorescence property. The diamine compound can be used for synthesizing high-performance and functional polymers such as polyamide, polyimide, polyamideimide and polyesterimide, and is especially suitable for preparing a soluble, colorless and transparent high-performance functional polyimide material with certain fluorescence property.