C₂₆H₂₆F₃N₅O₂S

Base Information

• Chemical Name: C₂₆H₂₆F₃N₅O₂S
• CAS No.: 1607461-50-6
• Molecular Formula: C₂₆H₂₆F₃N₅O₂S
• Molecular Weight: 529.586
• Mol file: 1607461-50-6.mol

Synonyms:

Chemical Property of C₂₆H₂₆F₃N₅O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₆F₃N₅O₂S

There total 13 articles about C₂₆H₂₆F₃N₅O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → C26H26F3N5O2S (1607461-50-6)

Guidance literature:

Multi-step reaction with 8 steps

1: tetrahydrofuran; diethyl ether

2: manganese(IV) oxide / dichloromethane

3: bromine / dichloromethane

4: acetonitrile

5: hydrogenchloride / 1,4-dioxane; water

6: sodium hydroxide / dimethyl sulfoxide / 120 °C

7: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

8: trifluoroacetic acid

With hydrogenchloride; manganese(IV) oxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

4-trifluoromethylphenylamine (455-14-1) → C26H26F3N5O2S (1607461-50-6)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrahydrofuran

2: sec.-butyllithium / tetrahydrofuran

3: hydrogenchloride / tetrahydrofuran; water; methanol / Heating

4: sodium nitrite; sodium hydroxide; sulfuric acid; tin(ll) chloride / water

5: sodium hydroxide / dimethyl sulfoxide / 120 °C

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

7: trifluoroacetic acid

With hydrogenchloride; sulfuric acid; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

Reference yield:

3-methyl-1-[3-(methyloxy)phenyl]-1-butanone (1183770-52-6) → C26H26F3N5O2S (1607461-50-6)

Guidance literature:

Multi-step reaction with 6 steps

1: bromine / dichloromethane

2: acetonitrile

3: hydrogenchloride / 1,4-dioxane; water

4: sodium hydroxide / dimethyl sulfoxide / 120 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

6: trifluoroacetic acid

With hydrogenchloride; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

3-methoxy-benzaldehyde

C₂₂H₁₈F₃N₃O₃S

1-(3-methoxyphenyl)-3-methylbutan-1-ol

3-methyl-1-[3-(methyloxy)phenyl]-1-butanone