(S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-ethyl]-cyclohexanone

Base Information

• Chemical Name: (S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-ethyl]-cyclohexanone
• CAS No.: 152429-15-7
• Molecular Formula: C₂₁H₃₃NO₂
• Molecular Weight: 331.499
• Mol file: 152429-15-7.mol

Synonyms:

Chemical Property of (S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-ethyl]-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-ethyl]-cyclohexanone

There total 1 articles about (S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-ethyl]-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-trimethylsilyloxy-2-methyl-1-cyclohexene (19980-35-9) + (1S,2R,6S,7R)-7,10,10-Trimethyl-4-((E)-propenyl)-3-oxa-5-aza-tricyclo[5.2.1.02,6]dec-4-ene (123821-03-4) → (S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.02,6]dec-4-en-4-yl)-ethyl]-cyclohexanone (152429-15-7) + (R)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.02,6]dec-4-en-4-yl)-ethyl]-cyclohexanone

Guidance literature:

With trifluoroacetic acid; calcium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -70 deg C, 10 min, 2.) CH₂Cl₂, from -70 to -40 deg C, 19 h;

DOI:10.1016/S0957-4166(00)80430-9

Reference yield: 100.0%

(S)-2-Methyl-2-[(R)-1-methyl-2-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.02,6]dec-4-en-4-yl)-ethyl]-cyclohexanone (152429-15-7) → (3R,1'S)-3-1'-methyl-2'-oxocyclohexanyl-butanoic acid (141610-87-9)

Guidance literature:

With hydrogenchloride; for 6.5h; Heating;

DOI:10.1016/S0957-4166(00)80430-9

upstream raw materials:

1-trimethylsilyloxy-2-methyl-1-cyclohexene

(1S,2R,6S,7R)-7,10,10-Trimethyl-4-((E)-propenyl)-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene

Downstream raw materials:

(3R,1'S)-3-1'-methyl-2'-oxocyclohexanyl-butanoic acid