(1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester

Base Information

• Chemical Name: (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester
• CAS No.: 134121-97-4
• Molecular Formula: C₁₇H₂₆N₂O₃S
• Molecular Weight: 338.471
• Mol file: 134121-97-4.mol

Synonyms:

Chemical Property of (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester

There total 5 articles about (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester (134121-97-4)

Guidance literature:

Multi-step reaction with 6 steps

1: t-BuOK

2: 43 percent / NBS, aqueous H₂SO₄

3: AgClO₄ / tetrahydrofuran / 0 °C

4: 1) t-BuOK

5: KBH₄ / ethanol

6: 1) NaH / THF, DMF

With N-Bromosuccinimide; potassium borohydride; sulfuric acid; potassium tert-butylate; silver perchlorate; sodium hydride; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4039(00)61206-6

Reference yield:

2-(pyridin-3-yl)-cyclohexanone (124034-66-8) → (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester (134121-97-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) t-BuOK

2: KBH₄ / ethanol

3: 1) NaH / THF, DMF

With potassium borohydride; potassium tert-butylate; sodium hydride; In ethanol;

DOI:10.1016/S0040-4039(00)61206-6

Reference yield:

(-)-N-methyl-2-oxo-1-(pyridin-3-yl)cyclohexanecarbothioamide (124034-07-7) → (1R,2S)-2-Hydroxy-N-methyl-1-pyridin-3-yl-cyclohexanecarboximidothioic acid 2-methoxy-ethoxymethyl ester (134121-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KBH₄ / ethanol

2: 1) NaH / THF, DMF

With potassium borohydride; sodium hydride; In ethanol;

DOI:10.1016/S0040-4039(00)61206-6

upstream raw materials:

3-pyridinecarboxaldehyde

2-(pyridin-3-yl)-cyclohexanone

(-)-N-methyl-2-oxo-1-(pyridin-3-yl)cyclohexanecarbothioamide

3-cyclopentylidenemethylpyridine

Downstream raw materials:

(1S,2R)-2-Methoxy-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide