2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

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Chemical Name:2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid
CAS No.:1403380-96-0
Molecular Formula:C₃₁H₃₃NO₆
Molecular Weight:515.606
Hs Code.:

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Chemical Property of 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

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Technology Process of 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

There total 11 articles about 2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1403380-96-0
2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

1.2: 17 h / -78 - 20 °C

2.1: thionyl chloride / 3 h / 85 °C

2.2: 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

8.1: perchloric acid / 1 h / -10 - 0 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

10.1: potassium hydroxide; water / ethanol / 5 h / 85 °C

10.2: pH 2

With hydrogenchloride; n-butyllithium; thionyl chloride; perchloric acid; water; sodium hydride; diisobutylaluminium hydride; sodium carbonate; diisopropylamine; acetyl chloride; potassium hydroxide; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 1403380-96-0
2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2.1: thionyl chloride / 3 h / 85 °C

2.2: 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

8.1: perchloric acid / 1 h / -10 - 0 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

10.1: potassium hydroxide; water / ethanol / 5 h / 85 °C

10.2: pH 2

With hydrogenchloride; dmap; thionyl chloride; perchloric acid; water; sodium hydride; diisobutylaluminium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; acetyl chloride; potassium hydroxide; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 227805-74-5
N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethan-1-amine

: 1403380-96-0
2-[4-benzyl-6-(3,4-dihydro-2H-1-benzopyran-6-yl)-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl]-2-(tert-butoxy)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 3 h / 85 °C

1.2: 15 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C

5.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

6.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

7.1: perchloric acid / 1 h / -10 - 0 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 16 h / 100 °C / Inert atmosphere

9.1: potassium hydroxide; water / ethanol / 5 h / 85 °C

9.2: pH 2

With hydrogenchloride; thionyl chloride; perchloric acid; water; sodium hydride; diisobutylaluminium hydride; sodium carbonate; acetyl chloride; potassium hydroxide; zinc(II) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;