C₁₁H₁₃ClO₂

Base Information

• Chemical Name: C₁₁H₁₃ClO₂
• CAS No.: 1442416-22-9
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.676
• Mol file: 1442416-22-9.mol

Synonyms:

Chemical Property of C₁₁H₁₃ClO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₁H₁₃ClO₂

There total 2 articles about C₁₁H₁₃ClO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-3-iodotetrahydrofuran (121138-01-0) + 2-(3-chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (929626-16-4) → C11H13ClO2 (1442416-22-9)

Guidance literature:

With nickel(II) bromide dimethoxyethane; bathophenanthroline; potassium tert-butylate; iso-butanol; In 1,4-dioxane; at 60 ℃; for 15h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201208203

Reference yield:

1-chloro-3-methoxy-benzene (2845-89-8) → C11H13ClO2 (1442416-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 18 h / 80 °C / Inert atmosphere; Glovebox

2: nickel(II) bromide dimethoxyethane; potassium tert-butylate; iso-butanol; bathophenanthroline / 1,4-dioxane / 15 h / 60 °C / Inert atmosphere; Glovebox

With nickel(II) bromide dimethoxyethane; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; bathophenanthroline; potassium tert-butylate; iso-butanol; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1002/anie.201208203

upstream raw materials:

(RS)-3-iodotetrahydrofuran

2-(3-chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-chloro-3-methoxy-benzene

Refernces