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3-IODO-TETRAHYDRO-FURAN is an organic compound that is characterized by the presence of a tetrahydrofuran ring with an iodine atom attached to the third carbon. It is a significant molecule in the field of organic chemistry and has potential applications in various industries due to its unique chemical properties.

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  • 121138-01-0 Structure
  • Basic information

    1. Product Name: 3-IODO-TETRAHYDRO-FURAN
    2. Synonyms: 3-IODO-TETRAHYDRO-FURAN;3-iodooxolane;Furan, tetrahydro-3-iodo-
    3. CAS NO:121138-01-0
    4. Molecular Formula: C4H7IO
    5. Molecular Weight: 198
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 121138-01-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 187.021 °C at 760 mmHg
    3. Flash Point: 66.908 °C
    4. Appearance: /
    5. Density: 1.931 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-IODO-TETRAHYDRO-FURAN(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-IODO-TETRAHYDRO-FURAN(121138-01-0)
    11. EPA Substance Registry System: 3-IODO-TETRAHYDRO-FURAN(121138-01-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 121138-01-0(Hazardous Substances Data)

121138-01-0 Usage

Uses

Used in Chemical Synthesis:
3-IODO-TETRAHYDRO-FURAN is used as a synthetic intermediate for the development of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
3-IODO-TETRAHYDRO-FURAN is used as a key component in the development of new drugs. Its ability to undergo various chemical reactions enables the creation of novel pharmaceutical compounds with potential therapeutic applications.
Used in Research and Development:
3-IODO-TETRAHYDRO-FURAN is used as a research tool in the study of transition-metal-free Heck-type reactions between alkenes and alkyl iodides enabled by light in water. This application is crucial for advancing the understanding of these reactions and their potential applications in the synthesis of various organic compounds.

Physical Form

liquid

Check Digit Verification of cas no

The CAS Registry Mumber 121138-01-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,1,3 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 121138-01:
(8*1)+(7*2)+(6*1)+(5*1)+(4*3)+(3*8)+(2*0)+(1*1)=70
70 % 10 = 0
So 121138-01-0 is a valid CAS Registry Number.

121138-01-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Iodotetrahydrofuran

1.2 Other means of identification

Product number -
Other names 3-iodooxolane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121138-01-0 SDS

121138-01-0Relevant articles and documents

Photoinduced Palladium-Catalyzed Dicarbofunctionalization of Terminal Alkynes

Yang, Zhen,Koenigs, Rene M.

supporting information, p. 3694 - 3699 (2021/02/01)

Herein, a conceptually distinct approach was developed that allowed for the dicarbofunctionalization of alkynes at room temperature using simple, bench-stable alkyl iodides and a second molecule of alkyne as coupling partner. Specifically, the photochemical activation of palladium complexes enabled this strategic dicarbofunctionalization via addition of alkyl radicals from secondary and tertiary alkyl iodides and formation of an intermediate palladium vinyl complex that could undergo subsequent Sonogashira reaction with a second alkyne molecule. This alkylation–alkynylation sequence allowed the one-step synthesis of 1,3-enynes including heteroarenes and biologically active compounds with high efficiency without exogenous photosensitizers or oxidants and now opens up pathways towards cascade reactions via photochemical palladium catalysis.

Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy

Liu, Xian-Guan,Dong, Ci-Shuang,Li, Fei,Zhang, Bo

supporting information, p. 4002 - 4007 (2021/05/26)

We report, for the first time, manganese-mediated direct functionalization of the Hantzsch esters with readily accessible alkyl iodides through an aromatization-dearomatization strategy. Applying this protocol, a library of valuable 4-alkyl-1,4-dihydropyridines were facilely afforded in good yields. This simple and practical reaction proceeds under visible-light irradiation at room temperature and displays high functional-group compatibility. Additionally, the method is applicable for gram-scale synthesis and late-stage functionalization of complex molecules.

Containing zinc binding moiety based EGFR tyrosine kinase inhibitors

-

Paragraph 0171; 0173-0175, (2016/10/17)

Belonging to the technical field of medicine, the invention in particular relates to a zinc binding group-containing quinazolinyl EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor shown as general formula (I), its deuterated compounds, pha

A transition-metal-free Heck-type reaction between alkenes and alkyl iodides enabled by light in water

Liu, Wenbo,Li, Lu,Chen, Zhengwang,Li, Chao-Jun

supporting information, p. 6170 - 6174 (2015/06/08)

A transition-metal-free coupling protocol between various alkenes and non-activated alkyl iodides has been developed by using photoenergy in water for the first time. Under UV irradiation and basic aqueous conditions, various alkenes efficiently couple with a wide range of non-activated alkyl iodides. A tentative mechanism, which involves an atom transfer radical addition process, for the coupling is proposed.

Combination of NH2OH·HCl and NaIO4: an effective reagent for molecular iodine-free regioselective 1,2-difunctionalization of olefins and easy access of terminal acetals

Chakraborty, Nirnita,Santra, Sougata,Kundu, Shrishnu Kumar,Hajra, Alakananda,Zyryanov, Grigory V.,Majee, Adinath

, p. 56780 - 56788 (2015/07/15)

We have demonstrated a new application of our oxidizing reagent, a combination of NH2OH·HCl and NaIO4, in the first generalized regioselective 1,2-difunctionalization of olefins. It is a general method for the preparation of β-iodo-β′-hydroxy ethers, β-iodo ethers, β-iodohydrin, and β-iodo acetoxy compounds using different reaction media. The reactions are highly regioselective, always affording Markovnikov's type addition products. The methodology is also applicable for the easy access of terminal acetals. Molecular iodine-free synthesis, room temperature reaction conditions, high yields, use of less expensive reagents, mild reaction conditions, broad applicability of nucleophiles, and applicability for gram-scale synthesis are the notable advantages of this present protocol.

Sterically controlled alkylation of arenes through iridium-catalyzed C-H borylation

Robbins, Daniel W.,Hartwig, John F.

supporting information, p. 933 - 937 (2013/02/25)

Complementary chemistry: A one-pot method for the site-selective alkylation of arenes controlled by steric effects is reported. The process occurs through Ir-catalyzed C-H borylation, followed by Pd- or Ni-catalyzed coupling with alkyl electrophiles. This selectivity complements that of the typical Friedel-Crafts alkylation; meta-selective alkylation of a broad range of arenes with various electronic properties and functional groups occurs in good yield with high site selectivity. Copyright

Br+ and I+ transfer from the halonium ions of adamantylideneadamantane to acceptor olefins. Halocyclization of 1,ω-alkenols and alkenoic acids proceeds via reversibly formed intermediates

Neverov,Brown

, p. 962 - 968 (2007/10/03)

The kinetics of the transfer of X+ from the bromonium and iodonium ions of adamantylideneadamantane (1-Br+ and 1-I+) to some 1,ω-alkenols and alkenoic acids in ClCH2CH2Cl at 25°C was investigated. In all cases, the expected products of halocyclization were observed. For the iodonium ion transfer the reaction kinetics are second order overall, first order in both 1-I+ and acceptor olefin. Transfer of the bromonium ion from 1-Br+ to these acceptor olefins exhibits different kinetic characteristics. In most cases, the rate of the Br+ transfer is subject to strong retardation in the presence of added parent olefin (Ad=Ad), suggestive of a common species rate depression. In some cases, such as 4-penten-1-ol (2b) and 4-pentenoic acid (4b), the reaction can be completely suppressed at high [Ad=Ad]. In other cases, such as 3-buten-1-ol (2a), 5-hexen-1-ol (2c), cyclohexene, 4-(hydroxymethyl)cyclohexene (3), and 5-endo-carboxynorbornene (5), added Ad=Ad does not suppress the reaction completely. In the cases of the 1,ω-alkenols, the reactions appear to exhibit kinetic terms that are greater than first order in alkenol. In these cases, alcohols such as 1-pentanol also accelerate the reaction, pointing to the involvement of the hydroxyl group of the second alkenol as a catalytic species. A unifying mechanism consistent with the data that involves two reversibly formed intermediates is presented.

Halocyclization of Unsaturated Alcohols and Carboxylic Acids Using Bis(sym-collidine)iodine(I) Perchlorate

Evans, Robert D.,Magee, Joseph W.,Schauble, J. Herman

, p. 862 - 868 (2007/10/02)

Reaction of I(collidine)2(1+) ClO4(1-) with unsaturated alcohols and carboxylic acids in dichloromethane at ambient temperature has afforded three- to seven-membered-ring iodoethers and four- to seven-membered-ring iodolactones, respectively, in moderate

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